The more you drink, the harder you fall: A systematic review and meta-analysis of how acute alcohol consumption and injury or collision risk increase together
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Alcohol consumption causes injury in a dose-response manner. The most common mode of sustaining an alcohol-attributable injury is from a single occasion of acute alcohol consumption, but much of the injury literature employs usual consumption habits to assess risk instead. An analysis of the acute dose-response relationship between alcohol and injury is warranted to generate single occasion- and dose-specific relative risks. A systematic literature review and meta-analysis was conducted to fill this gap. Linear and best-fit first-order model were used to model the data. Usual tests of heterogeneity and publication bias were run. Separate meta-analyses were run for motor vehicle and non-motor vehicle injuries, as well as case-control and case-crossover studies. The risk of injury increases non-linearly with increasing alcohol consumption. For motor vehicle accidents, the odds ratio increases by 1.24 (95% CI: 1.18-1.31) per 10-g in pure alcohol increase to 52.0 (95% CI: 34.50-78.28) at 120g. For non-motor vehicle injury, the OR increases by 1.30(95% CI: 1.26-1.34) to an OR of 24.2 at 140g (95% CI: 16.2-36.2). Case-crossover studies of non-MVA injury result in overall higher risks than case-control studies and the per-drink increase in odds of injury was highest for intentional injury, at 1.38 (95% CI: 1.22-1.55). Efforts to reduce drinking both on an individual level and a population level are important. No level of consumption is safe when driving and less than 2 drinks per occasion should be encouraged to reduce the risk of injury. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
URI
http://repositorio.inprf.gob.mx/handle/123456789/5336https://doi.org/10.1016/j.drugalcdep.2010.02.011
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887748/
Colecciones
Fecha
2010Autor
Nivel de acceso
acceso cerrado
Nombre de la Rev. [SO]
Drug and alcohol dependence
Publisher
ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Volumen [VL], Número [SU], Paginación [PG]
110 (1-2) 108-116 p. versión del editor
Idioma [LA]
eng
Tipo de documento [TP]
article
DOI [DO]
10.1016/j.drugalcdep.2010.02.011