The Latest Evidence in the Neuroscience of Solvent Misuse: An Article Written for Service Providers
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This work reviews preclinical and clinical studies published during the past two decades on the cellular and behavioral effects of commonly misused solvents. In animals, acute solvent exposure produces motor impairment and antidepressant- and anxiolytic-like effects. Human intoxication from misusing solvents is similar to that of ethanol; however, hallucinations and sudden sniffing death may occur at high solvent concentrations. Among chronic misusers, there is evidence of impaired memory, increased prevalence of psychiatric disorders, and neurological damage. Solvents facilitate inhibitory neurotransmission and block excitatory mechanisms. Toluene, in particular, increases brain dopamine levels and its effects occur at concentrations that do not dissolve cell membranes; therefore, neuronal damage is not an immediate, unavoidable consequence of solvent misuse
URI
http://repositorio.inprf.gob.mx/handle/123456789/5389https://doi.org/10.3109/10826084.2011.580215
Colecciones
Fecha
2011Autor
Nivel de acceso
acceso cerrado
Nombre de la Rev. [SO]
Substance use & misuse
Publisher
Informa Healthcare, Telephone House, 69-77 Paul Street, London EC2A 4LQ, England
Volumen [VL], Número [SU], Paginación [PG]
46 (1) 62-67 p. versión del editor
Idioma [LA]
eng
Palabras clave otro idioma [KO], Descriptores [Mesh], Descriptores [Meshm]
Tipo de documento [TP]
article
DOI [DO]
10.3109/10826084.2011.580215