Childhood Adversity, Early-Onset Depressive/Anxiety Disorders, and Adult-Onset Asthma
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Objectives: To investigate a) whether childhood adversity predicts adult-onset asthma; b) whether early-onset depressive/anxiety disorders predict adult-onset asthma; and c) whether childhood adversity and early-onset depressive/anxiety disorders predict adult-onset asthma independently of each other. Previous research has suggested, but not established, that childhood adversity may predict adult-onset asthma and, moreover, that the association between mental disorders and asthma may be a function of shared risk factors, such as childhood adversity. Methods: Ten cross-sectional population surveys of household-residing adults (> 18 years, n = 18,303) assessed mental disorders with the Composite International Diagnostic Interview (CIDI 3.0) as part of the World Mental Health surveys. Assessment of a range of childhood family adversities was included. Asthma was ascertained by self-report of lifetime diagnosis and age of diagnosis. Survival analyses calculated hazard ratios (HRs) for risk of adult-onset (>age 20 years) asthma as a function of number and type of childhood adversities and early-onset (<age 21 years) depressive and anxiety disorders, adjusting for current age, sex, country, education, and current smoking. Results: Childhood adversities predicted adult-onset asthma with risk increasing with the number of adversities experienced (HRs = 1.49-1.71). Early-onset depressive and anxiety disorders also predicted adult-onset asthma (HRs = 1.67-2.11). Childhood adversities and early-onset depressive and anxiety disorders both predicted adult-onset asthma after mutual adjustment (HRs = 1.43-1.91). Conclusions: Childhood adversities and early-onset depressive/anxiety disorders independently predict adult-onset asthma, suggesting that the mental disorder-asthma relationship is not a function of a shared background of childhood adversity.
URI
http://repositorio.inprf.gob.mx/handle/123456789/5277http://doi.org/10.1097/PSY.0b013e318187a2fb
Colecciones
Fecha
2008Autor
Nivel de acceso
acceso cerrado
Nombre de la Rev. [SO]
Psychosomatic medicine
Publisher
LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
Volumen [VL], Número [SU], Paginación [PG]
70 (9) 1035-1043 p. versión del editor
Idioma [LA]
eng
Tipo de documento [TP]
article
DOI [DO]
10.1097/PSY.0b013e318187a2fb