Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase

2017-06-302026-03-272017-06-302011Juan Carlos Bautista Ramírez0022-079510.1530/JOE-11-0248https://doi.org/10.1530/JOE-11-0248https://repositorio.inprf.gob.mx/handle/123456789/6194engacceso cerradoThyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinasearticle1479-68051Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz73-78Inglaterra211AminopeptidasesmetabolismAnimalsAntithyroid Agentsadverse effectsDisease Models, AnimalHypothyroidismchemically inducedHypothyroidismmetabolismInjections, IntraperitonealIodide PeroxidasegeneticsIodide PeroxidasemetabolismMiceMice, Inbred C57BLMice, KnockoutParaventricular Hypothalamic NucleusmetabolismParaventricular Hypothalamic NucleuspathologyPyrrolidonecarboxylic Acidanalogs & derivativesPyrrolidonecarboxylic AcidmetabolismRNA, Messengerantagonists & inhibitorsRNA, MessengermetabolismThyrotropinantagonists & inhibitorsThyrotropinmetabolismThyrotropin-Releasing Hormoneantagonists & inhibitorsThyrotropin-Releasing HormonemetabolismThyroxineadministration & dosageThyroxinepharmacologyTriiodothyronineadministration & dosageTriiodothyroninepharmacologyAntithyroid AgentsRNA, MessengerThyrotropin-Releasing HormoneTriiodothyronineThyroxineThyrotropinPyrrolidonecarboxylic Acidiodothyronine deiodinase type IIIodide PeroxidaseAminopeptidasespyroglutamyl-peptidase II