2017-06-302026-03-272017-06-302008Tomás Martínez Ibarra10.1186/1756-0500-1-134https://doi.org/10.1186/1756-0500-1-134https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627911/https://repositorio.inprf.gob.mx/handle/123456789/6818Background: Adynamia in fibromyalgia (FM) may be an expression of a functional deficit of the hypothalamic-pituitary-adrenal axis and be associated with below-normal levels of urinary cortisol. Our aim was to demonstrate that urinary cortisol was lower in patients with FM than in healthy subjects. Findings: We measured urinary cortisol levels for a sample of 47 women aged 29 to 64 years (mean age 53 years), diagnosed with FM 2–3 years previously, and compared the results with those for a control sample of 58 healthy women of a similar age. Samples of 24-hour urine were appropriately collected and levels of urinary cortisol were measured using the fluorescence polarization immunoassay method. The mean cortisol value for the women with FM was 65.40 ± 27.10 _g/L, significantly lower than the mean cortisol level for the control group, at 90.83 ± 38.17 _g/L (p < 0.001). Conclusion: Our study confirms that women with FM have significantly lower urinary cortisol levels than healthy women.engacceso cerradoarticle1756-05001Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.1-4Londres134