2017-06-292026-03-272017-06-292009Tomás Martínez Ibarra0007-125010.1192/bjp.bp.108.052159   https://doi.org/10.1192/bjp.bp.108.052159https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794248/https://repositorio.inprf.gob.mx/handle/123456789/5318Background: Community studies about the association of headache with both childhood family adversities and depression/anxiety disorders are limited. Aims: To assess the independent and joint associations of childhood family adversities and early-onset depression and anxiety disorders with risks of adult-onset headache. Method: Data were pooled from cross-sectional community surveys conducted in ten Latin and North American, European and Asian countries (n-18303) by using standardised instruments. Headache and a range of childhood family adversities were assessed by self-report. Results: The number of childhood family adversities was associated with adult-onset headache after adjusting for gender, age, country and early-onset depression/anxiety disorder status (for one adversity, hazard ratio (HR)=1.22-1.6; for two adversities, HR=11.19-1.67; for three or more adversities, HR=1.37-1.95). Early and Current onset of depression/anxiety disorders were independently associated (HR=1.42-1.89) with adult onset headache after controlling for number of childhood family adversities. Conclusions: The findings call for a broad developmental perspective concerning risk factors for development of headache.engacceso cerradoarticle2Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz111-116Londres194World Health OrganizationDiagnostic Interview CIDIComorbidity surveyMigraineDepressionAbuseHistoryWomenValidityVersionOrganización Mundial de la SaludEntrevista DiagnósticaEncuesta de comorbilidadMigrañaDepresiónAbusoHistoriaMujeresValidezVersión