Natural marine products as antiprotozoal agents against amitochondrial parasites

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dc.contributor.affiliationLaboratorio de Fitoquímica, UBIPRO, FES-Iztacala, Unidad Nacional Autónoma de México, Av. De los Barrios No.1, Los Reyes Iztacala, Tlalnepantla, 54090, Estado de México, Mexico
dc.contributor.emailmaria.alvarez@uacm.edu.mx, elizbeth2@gmail.com (M.E. Álvarez-Sánchez)
dc.creatorEstrella-Parra, Edgar Antonioes_ES
dc.creatorArreola, Rodrigoes_ES
dc.creatorÁlvarez-Sánchez, Maria Elizbethes_ES
dc.creatorTorres-Romero, Julio Césares_ES
dc.creatorRojas-Espinosa, Oscares_ES
dc.creatorDe la Cruz-Santiago, José Albertoes_ES
dc.creatorMartinez-Benitez, Máximo Bertoes_ES
dc.creatorLópez-Camarillo, Cesares_ES
dc.creatorLara-Riegos, Julio Cesares_ES
dc.creatorArana-Argáez, Víctor E.es_ES
dc.creatorRamírez-Camacho, Mario A.es_ES
dc.date2022
dc.date.accessioned2024-12-11T16:51:59Z
dc.date.accessioned2026-03-27T15:30:47Z
dc.date.available2024-12-11T16:51:59Z
dc.date.issued2022
dc.date.published2022
dc.descriptionThe goal of this work is to compile and discuss molecules of marine origin reported in the scientific literature with anti-parasitic activity against Trichomonas, Giardia, and Entamoeba, parasites responsible for diseases that are major global health problems, and Microsporidial parasites as an emerging problem. The presented data correspond to metabolites with anti-parasitic activity in human beings that have been isolated by chromatographic techniques from marine sources and structurally elucidated by spectroscopic and spectrometric procedures. We also highlight some semi-synthetic derivatives that have been successful in enhancing the activity of original compounds. The biological oceanic reservoir offers the possibility to discover new biologically active molecules as lead compounds to develop new drug candidates. The molecular variety is extensive and must be correctly explored and managed. Also, it will be necessary to take some actions to preserve the source species from extinction or overharvest (e.g., by cryopreservation of coral spermatozoa, oocytes, embryos, and larvae) and coordinate appropriate exploitation to increase the chemical knowledge of the natural products generated in the oceans. Additional initiatives such as the total synthesis of complex natural products and their derivatives can help to prevent overharvest of the marine ecosystems and at the same time contribute to the discovery of new molecules.es_ES
dc.formatPDFes_ES
dc.identifierOE09IC22es_ES
dc.identifier.doi10.1016/j.ijpddr.2022.05.003
dc.identifier.eissn2211-3207
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://doi.org/10.1016/j.ijpddr.2022.05.003
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8148
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation19:40-46
dc.relation.jnabreviadoINT J PARASITOL DRUGS DRUG RESIST
dc.relation.journalInternational Journal for Parasitology. Drugs and Drug Resistance
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAntiprotozoal
dc.subject.kwEntamoeba
dc.subject.kwGiardia
dc.subject.kwMicrosporidia
dc.subject.kwParasites
dc.subject.kwTrichomonas
dc.titleNatural marine products as antiprotozoal agents against amitochondrial parasiteses_ES
dc.typeArtículoes_ES

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