Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT1A agonists

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dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México, D.F., México.es_ES
dc.creatorLópez-Rubalcava, C.
dc.creatorFernández-Guasti, A.
dc.creator.identificador"http://orcid.org/0000-0002-9562-7193">López Rubalcava, Carolinaes_ES
dc.date.accessioned2017-06-29T04:17:31Z
dc.date.accessioned2026-03-27T14:35:11Z
dc.date.available2017-06-29T04:17:31Z
dc.date.issued1994es_ES
dc.date.published1994es_ES
dc.description.abstractotrodiomaThe purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-HT1A agonists including ipsapirone, buspirone, indorenate and 8-OH-DPAT. To this end, the effects of different closes of the adrenergic compounds clonidine (0.015-0.0625 mg-kg), yohimbine (0.125-0.5 mg-kg), prazosin (0.5-2.0 mg-kg), pindolol (1.55-6.2mg-kg) and practolol (0.25-1.0 mg-kg) on defensive burying behaviour were established. Clonidine (0.015-0.0625 mg-kg), prazosin (1.0 and 2.0 mg-kg), pindolol (1.55 and 6.2 mg-kg) and all 5-HT1A agonists reduced burying behaviour by themselves. In contrast, yohimbine (0.250 and 0.5 mg-kg) increased, while practolol did not modify, this behaviour. Additionally, the actions of yohimbine (0.125 mg-kg), prazosin (0.5 mg-kg), pindolol (3.1 mg-kg) and practolol (0.5 mg-kg) on the effects of ipsapirone (5.0 mg-kg), buspirone (5.0 mg-kg), indorenate (5.0 mg-kg) and 8-OH-DPAT (0.25 mg-kg) were examined. Prazosin enhanced the effects of ipsapirone, indorenate and buspirone, while yohimbine antagonized the actions of indorenate and 8-OH-DPAT. Pindolol enhanced the effects of indorenate while practolol antagonized the actions of ipsapirone, buspirone and 8-OH-DPAT. Only buspirone (5.0 mg-kg) affected motor coordination, an effect that was not counteracted by the antagonists. Based on these data an interaction between 5-HT1A agonists and the noradrenergic system in the regulation of anxiety is proposedes_ES
dc.description.monthFebes_ES
dc.identifier183es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.eissn1473-5849es_ES
dc.identifier.issn0955-8810es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion42-51es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4877
dc.identifier.volumen5es_ES
dc.language.isoenges_ES
dc.relation5 (1) 42-51 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoBEHAV PHARMACOLes_ES
dc.relation.journalBehavioural Pharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.ko[alpha]-Adrenergic antagonistses_ES
dc.subject.ko[beta]-Adrenergic antagonistses_ES
dc.subject.koAnxiety, Burying behaviores_ES
dc.subject.ko5-HT1A anxiolyticses_ES
dc.subject.koSerotonin-noradrenaline interactionses_ES
dc.titleNoradrenaline-serotonin interactions in the anxiolytic effects of 5-HT1A agonistses_ES
dc.typearticlees_ES

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