Ethanol exposure differentially alters pro-enkephalin mRNA expression in regions of the mesocorticolimbic system

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dc.contributor.affiliationDepartamento de Neuroquímica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente, Calzada México Xochimilco 101, Col. San Lorenzo Huipulco, 14370, México DF, Méxicoes_ES
dc.contributor.emailubach@imp.edu.mxes_ES
dc.creatorMéndez, Milagros
dc.creatorMorales-Mulia, Marcela
dc.creator.identificador"MEUM570510MDFNBL05">Méndez Ubach, Milagroses_ES
dc.date.accessioned2017-06-29T04:39:43Z
dc.date.accessioned2026-03-27T14:35:41Z
dc.date.available2017-06-29T04:39:43Z
dc.date.issued2006es_ES
dc.date.published2006es_ES
dc.description.abstractotrodiomaRATIONALE: Opioid peptides have been suggested to play a major role in ethanol reinforcement mechanisms and alcohol drinking behaviour. However, in non-selected strains of rodents, it is not known whether opioid biosynthesis is a critical event in these processes. OBJECTIVE: The aim of this work was to study the effects of a high dose of ethanol (2.5 g/kg body weight) on pro-enkephalin (pro-enk) mRNA expression in brain regions of the mesocorticolimbic system for up to 24 h after drug administration. MATERIALS AND METHODS: Male Wistar rats were administered with ethanol (2.5 g/kg body weight) or distilled water and were killed 30 min, 1, 2, 4, 8 or 24 h after treatment. Coronal brain sections (20 mu) were obtained and pro-enk mRNA expression was studied by in situ hybridization and densitometry. RESULTS: Acute ethanol administration induced a transient decrease and increase in pro-enk mRNA expression in the ventral tegmental area (33.2%) and prefrontal cortex (26.5%) 2 and 4 h after treatment, respectively. In contrast, ethanol induced prolonged increases in pro-enk mRNA expression in the core and shell regions of the nucleus accumbens, with different kinetics. Maximal effects were observed 2 h after ethanol exposure (core, 70.0%; shell, 60.0%). CONCLUSIONS: Our results indicate that enkephalin expression in regions of the rat mesocorticolimbic system is differentially altered by acute ethanol treatment and suggest that enkephalins may play a key role in ethanol reinforcement mechanismses_ES
dc.description.monthNoves_ES
dc.identifier499es_ES
dc.identifier.citationJosé Artemio Hernández Martínezes_ES
dc.identifier.doi10.1007/s00213-006-0503-3es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion117-124es_ES
dc.identifier.placeAlemaniaes_ES
dc.identifier.urihttps://doi.org/10.1007/s00213-006-0503-3es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/5186
dc.identifier.volumen189es_ES
dc.language.isoenges_ES
dc.relation189 (1) 117-124 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAlcoholes_ES
dc.subject.koEthanoles_ES
dc.subject.koOpioid peptideses_ES
dc.subject.koEnkephalinses_ES
dc.subject.koPro-enkephalin mRNAes_ES
dc.subject.koMesocortico limbic systemes_ES
dc.titleEthanol exposure differentially alters pro-enkephalin mRNA expression in regions of the mesocorticolimbic systemes_ES
dc.typearticlees_ES

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