Anti-depressant-like effect of kaempferitrin isolated from justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: Evidence for the involvement of the serotonergic system

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dc.contributor.affiliationDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Mexico D.F. 04960, Mexicoes_ES
dc.contributor.emailcasnij@hotmail.com, danna196799@hotmail.com, mayagn@imp.edu.mx, real474@imp.edu.mxes_ES
dc.creatorCassani, Julia
dc.creatorDorantes-Barrón, Ana María
dc.creatorMayagoitia Novales, Lilian
dc.creatorAlva Real, Guadalupe
dc.creatorEstrada-Reyes, Rosa
dc.creator.identificadorCAHJ690610MTLSRL08>Cassani, Juliaes_ES
dc.creator.identificadorEARR640516MMCSYS04>Estrada Reyes, Rosaes_ES
dc.date.accessioned2017-06-29T03:41:35Z
dc.date.accessioned2026-03-27T14:33:33Z
dc.date.available2017-06-29T03:41:35Z
dc.date.issued2014es_ES
dc.date.published2014es_ES
dc.description.abstractotrodiomaWe evaluated the antidepressant-like effect of kaempferitrin (Km) isolated from the plant Justicia spicigera (Asteraceae), which is used in traditional medicine for relieving emotional disorders, such as "la tristeza" (sadness or dysthymia) and "el humor" (mood changes). The actions of Km were evaluated in a forced swimming test (FST) and a suspension tail test (TST) in mice. We explored the involvement of the serotonergic system and the hypothalamic-hypophysis-adrenal axis (HPA) in the antidepressant-like effect of Km. To evaluate nonspecific effects of Km on general activity, the open field test (OFT) was performed. Km at 5, 10, and 20 mg/kg induced an antidepressant-like effect. Sub-effective dose of Km (1 mg/kg) produced a synergistic effect with imipramine (6.25 mg/kg) and fluoxetine (10 mg/kg) but not with desipramine (3.12 mg/kg). Pretreatment with p-chlorophenylalanine methyl ester (PCPA), a serotonin synthesis inhibitor, N-{2-(4-(2-methoxyphenyl)-1-piperazinyl}-N-(2-pyridinyl)cyclohexecarboxamide (WAY-100635), a selective 5-HT1A receptor antagonist, and 8OH-DPAT, a selective 5-HT1A agonist, but not pindolol (10 mg/kg) blocked the anti- immobility effect induced by Km. Taken together, these results indicate that the antidepressant-like effect of Km is related to the serotonergic system, principally 5-HT1A. This effect was not related to changes in locomotor activityes_ES
dc.description.monthDices_ES
dc.identifier2542es_ES
dc.identifier.citationElizabeth Cuesta Hernándezes_ES
dc.identifier.doi10.3390/molecules191221442es_ES
dc.identifier.issn1420-3049es_ES
dc.identifier.numero12es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion21442-21461es_ES
dc.identifier.placeSuizaes_ES
dc.identifier.urihttps://doi.org/10.3390/molecules191221442es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4391
dc.identifier.volumen19es_ES
dc.language.isoenges_ES
dc.publisherBasel, Switzerland : MDPIes_ES
dc.relation19(12) 21442-21461p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoMOLECULESes_ES
dc.relation.journalMolecules : A journal of synthetic chemistry and natural product chemistryes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAntidepressantes_ES
dc.subject.koMuitlees_ES
dc.subject.koJusticia spicigeraes_ES
dc.subject.koSerotonergic actionses_ES
dc.subject.koKaempferitrines_ES
dc.subject.meshAcanthaceae-Chemistryes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive agents-Pharmacologyes_ES
dc.subject.meshCorticosterone-Bloodes_ES
dc.subject.meshDrug evaluationes_ES
dc.subject.meshPreclinicales_ES
dc.subject.meshKaempferols-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshPlant extracts-Pharmacologyes_ES
dc.subject.meshReceptores_ES
dc.subject.meshSerotonines_ES
dc.subject.mesh5-HT1A-Metabolismes_ES
dc.subject.meshSerotonergic neurons-Drug effectses_ES
dc.subject.meshSwimminges_ES
dc.titleAnti-depressant-like effect of kaempferitrin isolated from justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: Evidence for the involvement of the serotonergic systemes_ES
dc.typeartículoes_ES

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