Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats

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dc.contributor.affiliationMolecular Neurophysiology Laboratory, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, Calz. México-Xochimilco No. 101, San Lorenzo Huipulco, CDMX, 14370, Mexico
dc.contributor.emailgortari@imp.edu.mx (P. de Gortari)
dc.creatorde Gortari, P.es_ES
dc.creatorAlcántara-Alonso, V.es_ES
dc.creatorMatamoros-Trejo, G.es_ES
dc.creatorAmaya, M. I.es_ES
dc.creatorAlvarez-Salas, E.es_ES
dc.date2020
dc.date.accessioned2023-06-02T17:06:29Z
dc.date.accessioned2026-03-27T15:26:12Z
dc.date.available2023-06-02T17:06:29Z
dc.date.issued2020
dc.date.published2020
dc.descriptionEarly-life overfeeding (OF) disrupts neuroendocrine systems, energy homeostasis and food intake regulation inducing overeating and overweight in adults. Adult rats raised in small litters during lactation, display hyperphagia and overweight since weaning and exhibit a decrease in thyrotropin-releasing hormone (TRH) mRNA expression in hypothalamic paraventricular nucleus (PVN). This is counterintuitive because TRH expression should increase to activate the hypothalamic-pituitary-thyroid (HPT) axis and promote energy expenditure, thus, HPT axis seems inhibited in OF rats. Leptin, an adipocyte-synthesized hormone that stimulates hypothalamic TRH expression, enhances both TRH anorectic effects and HPT axis-induced metabolic rate. To evaluate hypothalamic resistance to the anorectic and HPT axis stimulatory actions of leptin, we injected leptin i.p. to ad libitum fed and to 48-h fasted adult control (reared in normal litters) and to small-litter reared (OF) male Wistar rats. Findings showed that HPT axis was still responsive to leptin, since PVN TRH mRNA levels, median eminence TRH release and T4 serum concentration increased in both, ad libitum and fasted OF rats after leptin administrations. Leptin was ineffective to reduce feeding of OF animals. By comparing leptin receptor (ObRb) expression changes between arcuate and PVN nuclei, we observed that arcuate ObRb was not modified in response to leptin administrations in OF rats, likely accounting for the differential effects in feeding and HPT axis function. Nevertheless, ObRb expression was modified by leptin in the PVN of OF rats to the same extent as controls; this supports the hormone's role as a therapeutic agent for early onset obesity in adults.es_ES
dc.formatPDFes_ES
dc.identifierJC16NC20es_ES
dc.identifier.doi10.1016/j.peptides.2020.170285
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2020.170285
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7704
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation127:170285
dc.relation.jnabreviadoPEPTIDES
dc.relation.journalPeptides
dc.rightsAcceso Cerradoes_ES
dc.subject.kwOverfeeding
dc.subject.kwThyrotropin-Releasing hormone
dc.subject.kwLeptin receptor
dc.subject.kwObesity
dc.titleDifferential effects of leptin administration on feeding and HPT axis function in early-life overfed adult ratses_ES
dc.typeArtículoes_ES

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