Selective estrogen receptor-alpha but not -beta agonist treatment modulates brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

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dc.contributor.affiliationMolecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL), and Faculty of Pharmacy, Laval University, Sainte-Foy, Québec, Canadaes_ES
dc.contributor.emailtherese.dipaolo@crchul.ulaval.caes_ES
dc.creatorLe Saux, Maryvonne
dc.creatorEstrada-Camarena, Erika
dc.creatorDi Paolo, Thérèse
dc.creator.identificador"EACE710206MVZSMR06">Estrada Camarena, Erika Monserrates_ES
dc.date.accessioned2017-06-30T01:34:07Z
dc.date.accessioned2026-03-27T14:46:59Z
dc.date.available2017-06-30T01:34:07Z
dc.date.issued2006es_ES
dc.date.published2006es_ES
dc.description.abstractotrodiomaEstradiol was previously reported to decrease brain alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-receptor-specific binding. The contributions of estrogen receptor subtypes in the estradiol modulation of AMPA receptors and its predominant subunit GluR2 are unknown. These experiments investigated whether an estrogenic receptor subtype is involved in the estradiol effect on AMPA-receptor-specific binding and GluR2 mRNA levels. Ovariectomized Sprague-Dawley rats were treated 2 days after ovariectomy for 2 weeks with 17beta-estradiol, an agonist for Eralpha 4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), or an agonist for Erbeta 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN) and compared with intact control rats. Uterus weights, used as aperipheral measure of estrogenic activity, were decreased after ovariectomy and increased by estradiol and PPT but not DPN treatments. In prefrontal and cingulate cortices, the striatum, and the nucleus accumbens, ovariectomy increased [3H]AMPA-specific binding compared with intact controls, which was corrected by estradiol treatment. In all these brain regions, PPT, but not DPN, mimicked the estradiol decrease of AMPA-receptor-specific binding; in the cingulate cortex, the effect of PPT did not reach statistical significance. GluR2 mRNA levels of vehicle-treated ovariectomized rats remained unchanged compared with intact rats in the brain regions investigated. Estradiol and PPT treatment but not DPN decreased GluR2 subunit mRNA levels in the prefrontal cortex and the striatum of ovariectomized rats, whereas no significant change was observed in the cingulate cortex or the nucleus accumbens. The present results suggest that an Eralpha is involved in the estradiol modulation of AMPA receptors in the cortex, striatum, and nucleus accumbenses_ES
dc.description.monthOctes_ES
dc.identifier1465es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1002/jnr.21007es_ES
dc.identifier.eissn1097-4547es_ES
dc.identifier.issn0360-4012es_ES
dc.identifier.numero5es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1076-1084es_ES
dc.identifier.placeEstados Unidoses_ES
dc.identifier.urihttps://doi.org/10.1002/jnr.21007es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6146
dc.identifier.volumen84es_ES
dc.language.isoenges_ES
dc.relation84 (5) 1076-1084 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ NEUROSCI RESes_ES
dc.relation.journalJournal of Neuroscience Researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnalysis of Variancees_ES
dc.subject.koAnimalses_ES
dc.subject.koAutoradiographyes_ES
dc.subject.koMethodses_ES
dc.subject.koBraines_ES
dc.subject.koDrug effectses_ES
dc.subject.koEstradioles_ES
dc.subject.koPharmacologyes_ES
dc.subject.koEstrogen Receptor alphaes_ES
dc.subject.koEstrogen Receptor betaes_ES
dc.subject.koAgonistses_ES
dc.subject.koFemalees_ES
dc.subject.koGinsenosideses_ES
dc.subject.koIn Situ Hybridizationes_ES
dc.subject.koOvariectomyes_ES
dc.subject.koProtein Bindinges_ES
dc.subject.koRatses_ES
dc.subject.koRats, Sprague-Dawleyes_ES
dc.subject.koReceptors, AMPAes_ES
dc.subject.koGeneticses_ES
dc.subject.koMetabolismes_ES
dc.subject.koReceptors, Estrogenes_ES
dc.subject.koSapogeninses_ES
dc.subject.koTritiumes_ES
dc.subject.koEstrogen receptor alpha, humanes_ES
dc.subject.koGinsenoside 20S-protopanaxatrioles_ES
dc.subject.koGlutamate receptor ionotropic, AMPA 2es_ES
dc.subject.kwAnálisis de varianzaes_ES
dc.subject.kwAnimaleses_ES
dc.subject.kwAutorradiografíaes_ES
dc.subject.kwMétodoses_ES
dc.subject.kwCerebroes_ES
dc.subject.kwEstradioles_ES
dc.subject.kwEfectos de drogases_ES
dc.subject.kwFarmacologíaes_ES
dc.subject.kwReceptor de estrógeno alfaes_ES
dc.subject.kwReceptor de estrógeno betaes_ES
dc.subject.kwAgonistases_ES
dc.subject.kwGinsenósidoses_ES
dc.subject.kwFemeninoes_ES
dc.subject.kwHibridación in situes_ES
dc.subject.kwOvariectomíaes_ES
dc.subject.kwProteína de uniónes_ES
dc.subject.kwRatases_ES
dc.subject.kwRatas Sprague-Dawleyes_ES
dc.subject.kwReceptores de AMPAes_ES
dc.subject.kwGenéticaes_ES
dc.subject.kwReceptores de Estrógenoes_ES
dc.subject.kwMetabolismoes_ES
dc.subject.kwSapogeninases_ES
dc.subject.kwTritioes_ES
dc.subject.kwReceptor de estrógeno alfa humanoes_ES
dc.subject.kwGinsenoside 20S-protopanaxatrioles_ES
dc.subject.kwIonotrópicos receptor de glutamato, AMPA 2es_ES
dc.titleSelective estrogen receptor-alpha but not -beta agonist treatment modulates brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorses_ES
dc.typearticlees_ES

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