Melatonin: a neurotrophic factor?

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dc.contributor.affiliationLaboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan 14370, Mexico City, Mexico
dc.contributor.emailgenarogabriel@yahoo.com (G.G.O.) ; bekin@imp.edu.mx (G.B.-K.)
dc.creatorMiranda-Riestra, Armidaes_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.creatorTorres-Sanchez, Erandis D.es_ES
dc.creatorCarreño-García, Silviaes_ES
dc.creatorGabriel Ortiz, Genaroes_ES
dc.creatorBenítez-King, Gloriaes_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-2673-5270 (Estrada-Reyes, Rosa)
dc.creator.identificadorhttps://orcid.org/0000-0002-8131-6853 (Torres-Sanchez, Erandis D.)
dc.creator.identificadorhttps://orcid.org/0000-0002-7054-3313 (Gabriel Ortiz, Genaro)
dc.creator.identificadorhttps://orcid.org/0000-0003-0959-6851 (Benítez-King, Gloria)
dc.date2022
dc.date.accessioned2025-01-17T17:30:30Z
dc.date.accessioned2026-03-27T15:31:05Z
dc.date.available2025-01-17T17:30:30Z
dc.date.issued2022
dc.date.published2022
dc.descriptionMelatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal environment with the photoperiod. It is synthesized in the pineal gland and greatly depends on the endogenous circadian clock located in the suprachiasmatic nucleus and the retina's exposure to different light intensities. Among its most studied functions are the regulation of the waking-sleep rhythm and body temperature. Furthermore, melatonin has pleiotropic actions, which affect, for instance, the modulation of the immune and the cardiovascular systems, as well as the neuroprotection achieved by scavenging free radicals. Recent research has supported that melatonin contributes to neuronal survival, proliferation, and differentiation, such as dendritogenesis and axogenesis, and its processes are similar to those caused by Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4/5. Furthermore, this indolamine has apoptotic and anti-inflammatory actions in specific brain regions akin to those exerted by neurotrophic factors. This review presents evidence suggesting melatonin's role as a neurotrophic factor, describes the signaling pathways involved in these processes, and, lastly, highlights the therapeutic implications involved.es_ES
dc.formatPDFes_ES
dc.identifierJC25NC22es_ES
dc.identifier.doi10.3390/molecules27227742
dc.identifier.eissn1420-3049
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/molecules27227742
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8203
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation27(22):7742
dc.relation.jnabreviadoMOLECULES
dc.relation.journalMolecules
dc.rightsAcceso Cerradoes_ES
dc.subject.kwMelatonin
dc.subject.kwNeurogenesis
dc.subject.kwPleiotropic
dc.subject.kwNeurotrophic factors
dc.subject.kwNeural differentiation
dc.titleMelatonin: a neurotrophic factor?es_ES
dc.typeArtículoes_ES

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