Role of the thyrotropin-releasing hormone of the limbic system in mood and eating regulation

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dc.contributor.affiliationMolecular Neurophysiology lab, Department of Neuroscience, National Institute of Psychiatry Ramón de la Fuente Muñiz, 14370 Mexico City, Mexico
dc.contributor.emailgortari@imp.edu.mx (Patricia de Gortari)
dc.creatorAlvarez-Salas, Elenaes_ES
dc.creatorGarcía-Luna, Cinthiaes_ES
dc.creatorSoberanes-Chávez, Paulinaes_ES
dc.creatorGortari, Patricia dees_ES
dc.date2022
dc.date.accessioned2025-01-07T18:36:02Z
dc.date.accessioned2026-03-27T15:31:01Z
dc.date.available2025-01-07T18:36:02Z
dc.date.issued2022
dc.date.published2022
dc.descriptionThyrotropin-releasing hormone (TRH) and its receptors are expressed in the hypothalamus and limbic regions. Brain thyrotropin-releasing hormone actions are exerted directly through its receptors and indirectly by modulating the effects of neurotransmitters such as glutamate, gamma-aminobutyric acid, acetylcholine, and dopamine. The thyrotropin-releasing hormone has been implicated in eating and mood regulation. We integrate studies that analyze the role of limbic thyrotropin-releasing hormone on displaying depressive- and anxiety-like behaviors and anorexia or hyperphagia. Since the decade of 1970s, different efforts have been made to identify some of the thyrotropin-releasing hormone effects and its analogs in feeding regulation or to ameliorate symptoms in patients diagnosed with mood disorders, and to correlate anxious or depressive parameters with thyrotropin-releasing hormone levels in the cerebrospinal fluid or its expression in postmortem brain areas of affected patients. Pharmacological studies where the thyrotropin-releasing hormone is administered to animals by different routes and to distinct brain areas have elucidated its actions in behavioral changes of mood and feeding parameters. In addition, a variety of animal models of depression, anxiety, or anorexia and hyperphagia has suggested the association between the hypothalamic and limbic TRHergic system and the regulation of mood and feeding alterations. Different approaches employ the administration of anti-depressant, anxiolytic or anorectic agents to animals and describe changes in thyrotropin-releasing hormone content or expression in hypothalamic or limbic regions. The different effects on mood that result from modulating thyrotropin-releasing hormone expression may be beneficial to treat patients diagnosed with eating disorders.es_ES
dc.formatPDFes_ES
dc.identifierJC36NC22es_ES
dc.identifier.doi10.31083/j.jin2102047
dc.identifier.issn0219-6352
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSingapur
dc.identifier.urihttps://doi.org/10.31083/j.jin2102047
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8190
dc.language.isoenges_ES
dc.publisherIMR Presses_ES
dc.relation21(2):47
dc.relation.jnabreviadoJ INTEGR NEUROSCI
dc.relation.journalJournal of Integrative Neuroscience
dc.rightsAcceso Cerradoes_ES
dc.subject.kwTRH
dc.subject.kwDepression
dc.subject.kwAnxiety
dc.subject.kwFeeding
dc.subject.kwHypothalamus
dc.subject.kwLimbic regions
dc.titleRole of the thyrotropin-releasing hormone of the limbic system in mood and eating regulationes_ES
dc.typeArtículoes_ES

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