Low doses of ketamine and melatonin in combination produce additive antidepressant-like effects in mice

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dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico.
dc.contributor.emailbekin@imp.edu.mx; bekin54@hotmail.com (Benítez-King, Gloria)
dc.creatorEstrada-Reyes, Rosaes_ES
dc.creatorQuero-Chávez, Daniel B.es_ES
dc.creatorTrueta, Citlalies_ES
dc.creatorMiranda, Armidaes_ES
dc.creatorValdés-Tovar, Marcelaes_ES
dc.creatorAlarcón-Elizalde, Salvadores_ES
dc.creatorOikawa-Sala, Juliánes_ES
dc.creatorArgueta, Jesúses_ES
dc.creatorConstantino-Jonapa, Luis A.es_ES
dc.creatorMuñoz-Estrada, Jesúses_ES
dc.creatorDubocovich, Margarita L.es_ES
dc.creatorBenítez-King, Gloriaes_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-2673-5270 (Estrada-Reyes, Rosa)
dc.creator.identificadorhttps://orcid.org/0000-0001-6567-3538 (Trueta, Citlali)
dc.creator.identificadorhttps://orcid.org/0000-0003-4991-6055 (Miranda-Riestra, Armida)
dc.creator.identificadorhttps://orcid.org/0000-0002-5540-7321 (Valdés-Tovar, Marcela)
dc.creator.identificadorhttps://orcid.org/0000-0003-0760-4192 (Alarcón-Elizalde, Salvador)
dc.creator.identificadorhttps://orcid.org/0000-0003-1736-1112 (Oikawa-Sala, Julián)
dc.creator.identificadorhttps://orcid.org/0000-0003-3668-1066 (Argueta, Jesús)
dc.creator.identificadorhttps://orcid.org/0000-0003-0773-2581 (Constantino-Jonapa, Luis A.)
dc.creator.identificadorhttps://orcid.org/0000-0003-0959-6851 (Benítez-King, Gloria)
dc.date2021
dc.date.accessioned2024-05-30T20:20:46Z
dc.date.accessioned2026-03-27T15:30:09Z
dc.date.available2024-05-30T20:20:46Z
dc.date.issued2021
dc.date.published2021
dc.descriptionMajor depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatment, making it necessary to search for new antidepressant treatments. Ketamine, a phencyclidine hydrochloride derivative, given intravenously, induces a rapid antidepressant effect in humans. In mice, it causes increased neurogenesis and antidepressant-like effects. However, it also produces psychomimetic effects in humans and in rodents increases the locomotor activity. In contrast, melatonin, a hormone secreted by the pineal gland and synthesized in extrapineal sites, increases new neuron formation and causes antidepressant-like effects in adult rodents with no collateral effects. Here, we assessed the effects of a non-effective dose of ketamine in combination with melatonin (KET/MEL), both on neurogenesis as well as on the antidepressant-like effect in mice. Our results showed that KET/MEL combination increased neurogenesis and produced antidepressant-like effects without altering locomotor activity after both single and triple administration protocols. Our data strongly suggest that KET/MEL combination could be used to simultaneously promote neurogenesis, reverting neuronal atrophy and inducing antidepressant-like effects.es_ES
dc.formatPDFes_ES
dc.identifierJC10NC21es_ES
dc.identifier.doi10.3390/ijms22179225
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/ijms22179225
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7982
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation22(17):9225
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerradoes_ES
dc.subject.kwMelatonin
dc.subject.kwKetamine
dc.subject.kwDepression
dc.subject.kwAntidepressant
dc.titleLow doses of ketamine and melatonin in combination produce additive antidepressant-like effects in micees_ES
dc.typeArtículoes_ES

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