Increased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsy

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dc.contributor.affiliationDepartment of Genetics, National Institute of Psychiatry "Ramón de la Fuente Muñiz" (INPRFM), Mexico DF, Mexico
dc.contributor.emailcruz@imp.edu.mx (C. S. Cruz-Fuentes)
dc.creatorMartínez-Levy, G. A.es_ES
dc.creatorRocha, L.es_ES
dc.creatorLubin, F. D.es_ES
dc.creatorAlonso-Vanegas, M. A.es_ES
dc.creatorNani, A.es_ES
dc.creatorBuentello-García, R. M.es_ES
dc.creatorPérez-Molina, R.es_ES
dc.creatorBriones-Velasco, M.es_ES
dc.creatorRecillas-Targa, F.es_ES
dc.creatorPérez-Molina, A.es_ES
dc.creatorSan-Juan, D.es_ES
dc.creatorCienfuegos, J.es_ES
dc.date2016
dc.date.accessioned2025-10-23T17:48:50Z
dc.date.accessioned2026-03-27T15:33:23Z
dc.date.available2025-10-23T17:48:50Z
dc.date.issued2016
dc.date.published2016
dc.descriptionA putative role of the brain-derived neurotrophic factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampi of patients with pharmaco-resistant temporal lobe epilepsy (TLE) (n=24). Hippocampal sclerosis (HS) and pre-surgical pharmacological treatment were considered as clinical independent variables. A statistical significant increase for the BDNFVI (p<0.05) was observed in TLE patients compared to the autopsy control group (n=8). BDNFVI was also increased in anxiety/depression TLE (N=4) when compared to autopsies or to the remaining group of patients (p<0.05). In contrast, the use of the antiepileptic drug Topiramate (TPM) (N=3) was associated to a decrease in BDNFVI expression (p<0.05) when compared to the remaining group of patients. Methylation levels at the BDNF promoters 4 and 6 were similar between TLE and autopsies and in relation to the use of either Sertraline (SRT) or TPM. These results suggest an up-regulated expression of a specific BDNF transcript in patients with TLE, an effect that seems to be dependent on the use of specific drugs.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.neuroscience.2015.11.046
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttp://dx.doi.org/10.1016/j.neuroscience.2015.11.046
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8476
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation314:12-21
dc.relation.jnabreviadoNEUROSCIENCE
dc.relation.journalNeuroscience
dc.rightsAcceso Cerradoes_ES
dc.subject.kwPharmaco-resistant temporal lobe epilepsy
dc.subject.kwBDNF
dc.subject.kwmRNA expression
dc.subject.kwEpigenetics
dc.subject.kwPromoter methylation
dc.subject.kwHuman
dc.titleIncreased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsyes_ES
dc.typeArtículoes_ES

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