Pharmacokinetic study of carbamazepine and its carbamazepine 10,11-epoxide metabolite in a group of female epileptic patients under chronic treatment

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dc.contributor.affiliationInst Nacl Psiquiatria Dr Ramon Fuente, Div Serv Clin, Clin Lab, Dr Ramon Fuente,Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailmoreno@imp.edu.mxes_ES
dc.creatorMoreno, Julia
dc.creatorBelmont, Aurora
dc.creatorJaimes, Orlando
dc.creatorSantos, José A.
dc.creatorLópez, Guadalupe
dc.creatorCampos, María G.
dc.creatorAmancio, Octavio
dc.creatorPérez, Patricia
dc.creatorHeinze, Gerardo
dc.creator.identificador"MOAJ550109MPLRGL06">Moreno Aguilar, Juliaes_ES
dc.date.accessioned2017-06-30T04:01:26Z
dc.date.accessioned2026-03-27T15:24:45Z
dc.date.available2017-06-30T04:01:26Z
dc.date.issued2004es_ES
dc.date.published2004es_ES
dc.description.abstractotrodiomaBackground. Although epileptic crises are equally frequent in women and men, several factors cause female epileptics to present a series of gender-specific problems. To date, few studies have been published on the kinetics of carbamazepine (CBZ) and carbamazepine 10,11-epoxide (CBZ-E) active metabolite in a Mexican population, and no information for epileptic women of reproductive age is available. The aim of the present work was to study the pharmacokinetic behavior of this group of women during steady state. Methods. Fourteen epileptic women under chronic treatment receiving only the anticonvulsant CBZ to control their crises were studied. A blood sample was taken before breakfast, before the morning dose of 200 mg, and after the dose at 1, 2, 3, 4, 5, and 8 h. Serum was separated by centrifugation at 1,350 x g. Serum concentrations of carbamazepine (CBZ) and of the metabolite carbamazepine 10,11-epoxide (CBZ-E) were measured by HPLC. Pharmacokinetic parameters were calculated by statistical moment method after obtaining serum concentrations. Results. Maximum time (T-max) for CBZ was reached at 2.72 +/- 0.71 h and for CBZ-E, it was 3.60 +/- 0.79 h. C-max for CBZ was 7.30 +/- 2.30 mug/mL, while C-min for CBZ was 6.30 +/- 2.49. Maximum serum values for CBZ-E were 1.01 +/- 0.57, equivalent to 13.80% of CBZ| t(1/2) value for CBZ and CBZ-E was 18.20 and 16.10 h, respectively. AUC values for CBZ and metabolite were 70.33 +/- 17.10 mug/L/h and 9.20 +/- 2.50 mug/L/h, respectively. CBZ and CBZ-E clearance did not show differences and were 0.37 mL/kg/min and 0.40 mL/kg/min, respectively. Extraction index for serum concentrations of CBZ and CBZ-E AUC(CBZ)/AUC(CBZ-E) was 0.13| positive correlation was observed between serum concentrations of CBZ and E-CBZ, with r = 0.94. Conclusions. The schedule we suggest for therapeutic monitoring of serum concentrations of CBZ in chronic treatments is 3 h for maximum peak concentration of C-max after dose administration and for minimum peak concentration, C-min prior to subsequent administration of the dose. (C) 2004 IMSS. Published by Elsevier Inc.es_ES
dc.description.monthAbres_ES
dc.identifier2457es_ES
dc.identifier.citationTomás Martínez Ibarraes_ES
dc.identifier.doi10.1016/j.arcmed.2003.09.016es_ES
dc.identifier.eissn1873-5487es_ES
dc.identifier.issn0188-4409es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.paginacion168-171es_ES
dc.identifier.placeNew Yorkes_ES
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2003.09.016es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7098
dc.identifier.volumen35es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAes_ES
dc.relation35 (2) 168-171 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoARCH MED RESes_ES
dc.relation.journalArchives of medical researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koCarbamazepinees_ES
dc.subject.koCarbamazepine 10,11-epoxidees_ES
dc.subject.koPharmacokinetices_ES
dc.subject.koEpileptices_ES
dc.subject.kwCarbamazepinaes_ES
dc.subject.kwCarbamazepina 10,11-epóxidoes_ES
dc.subject.kwFarmacocinéticaes_ES
dc.subject.kwEpilépticoes_ES
dc.titlePharmacokinetic study of carbamazepine and its carbamazepine 10,11-epoxide metabolite in a group of female epileptic patients under chronic treatmentes_ES
dc.typearticlees_ES

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