Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia and c-fos Activation but Not Experimental Anxiety or Depression in a Menopause Model

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dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente", Mexico City 14370, Mexico
dc.contributor.emailestrada@imp.edu.mx
dc.creatorVega-Rivera, Nelly Maritza
dc.creatorEstrada-Camarena, Erika
dc.creatorAzpilcueta-Morales, Gabriel
dc.creatorCervantes-Anaya, Nancy
dc.creatorTreviño, Samuel
dc.creatorBecerril-Villanueva, Enrique
dc.creatorLópez-Rubalcava, Carolina
dc.creator.identificadorhttps://orcid.org/0000-0001-6634-7494 (Estrada-Camarena, Erika)
dc.creator.identificadorhttps://orcid.org/0000-0002-7605-1045 (Azpilcueta-Morales, Gabriel)
dc.creator.identificadorhttps://orcid.org/0000-0001-5679-1671 (Treviño, Samuel)
dc.creator.identificadorhttps://orcid.org/0000-0001-7210-9775 (Becerril-Villanueva, Enrique)
dc.creator.identificadorhttps://orcid.org/0000-0002-9562-7193 (López-Rubalcava, Carolina)
dc.date2024
dc.date.accessioned2026-06-17T16:10:02Z
dc.date.issued2024
dc.date.published2024
dc.descriptionThe menopause transition is a vulnerable period for developing both psychiatric and metabolic disorders, and both can be enhanced by stressful events worsening their effects. The present study aimed to evaluate whether a cafeteria diet (CAF) combined with chronic variable stress (CVS) exacerbates anxious- or depressive-like behavior and neuronal activation, cell proliferation and survival, and microglia activation in middle-aged ovariectomized (OVX) rats. In addition, body weight, lipid profile, insulin resistance, and corticosterone as an index of metabolic changes or hypothalamus-pituitary-adrenal (HPA) axis activation, and the serum pro-inflammatory cytokines IL-6, IL-β, and TNFα were measured. A CAF diet increased body weight, lipid profile, and insulin resistance. CVS increased corticosterone and reduced HDL. A CAF produced anxiety-like behaviors, whereas CVS induced depressive-like behaviors. CVS increased serum TNFα independently of diet. A CAF and CVS separately enhanced the percentage of Iba-positive cells in the hippocampus; the combination of factors further increased Iba-positive cells in the ventral hippocampus. A CAF and CVS increased the c-fos-positive cells in the hippocampus; the combination of factors increased the number of positive cells expressing c-fos in the ventral hippocampus even more. The combination of a CAF and CVS generates a slight neuroinflammation process and neuronal activation in a hippocampal region-specific manner and differentially affects the behavior.
dc.formatPDF
dc.identifierJC10NC24
dc.identifier.doi10.3390/ijms25031455
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/108
dc.identifier.urihttps://doi.org/10.3390/ijms25031455
dc.language.isoeng
dc.publisherMDPI
dc.relation25(3):1455
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerrado
dc.subject.kwChronic variable stress
dc.subject.kwMenopause model
dc.subject.kwObesity
dc.subject.kwAnxiety
dc.subject.kwIba-positive cells
dc.subject.kwc-fos
dc.titleChronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia and c-fos Activation but Not Experimental Anxiety or Depression in a Menopause Model
dc.typeArtículo

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