Neuropharmacological studies of Piper auritum Kunth (Piperaceae): antinociceptive and anxiolytic-like effects

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dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Delegación Tlalpan, México City, 14370, Mexico.es_ES
dc.contributor.emailrestrada@imp.edu.mxes_ES
dc.creatorEstrada-Reyes, R
dc.creatorMartínez-Laurrab, A
dc.creatorUbaldo Suárez, D
dc.creatorAraujo-Escalona, AG
dc.creator.identificador"EARR640516MMCSYS04">Estrada-Reyes, R.es_ES
dc.date.accessioned2017-06-29T04:01:21Z
dc.date.accessioned2026-03-27T14:33:25Z
dc.date.available2017-06-29T04:01:21Z
dc.date.issued2013es_ES
dc.date.published2013es_ES
dc.description.abstractotrodiomaP. auritum Kunth leaves commonly known as “hierba santa” or “acuyo” or false Kava is used in Mexican Traditional Medicine as a tranquilizing and appetite stimulant agent, as well as a remedy for the relief of headache. The objective of the present work was to evaluate the effects of organic and aqueous extracts of Piper auritum Kunth (Piperaceae) leaves on the Central Nervous System (CNS) in mice. For acute toxicity evaluation, the LD50 of all extracts were determined according to Locke's method. Effects of both the organic and aqueous extracts of P. auritum leaves were tested in sodium pentobarbitalinduced sleep, hot plate and open field tests. The anxiolytic-like effects were determined in burying behavior and hole-board models. In this study we demonstrated for the first time that both organic and aqueous extracts of the leaves of P. auritum possess antinociceptive effect while at higher doses the organic extracts exert a depressant effect on the CNS in mice. The aqueous extract showed antinociceptive and anxiolytic-like effects in the model tested, without affecting the locomotor activity of experimental animals. Acute toxicity tests show that the intake of extracts of different polarities of P. auritum involves no health risks. The present study supports, in part, the uses of P. auritum leaves as a tranquilizer, sedative agent, and as a remedy for the relief of pain in Mexican traditional medicine.es_ES
dc.description.monthJunes_ES
dc.identifier2846es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.doi10.5897/JMPR12.1154es_ES
dc.identifier.eissn1996-0875es_ES
dc.identifier.numero23es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1718-1729es_ES
dc.identifier.placeNigeriaes_ES
dc.identifier.urihttps://doi.org/10.5897/JMPR12.1154
dc.identifier.urihttps://academicjournals.org/journal/JMPR/article-abstract/E7EBF2027073es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4695
dc.identifier.volumen7es_ES
dc.language.isoenges_ES
dc.publisherLagos : Academic Journalses_ES
dc.relation7 (23) 1718-1729 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ MED PLANT RESes_ES
dc.relation.journalJournal of Medicinal Plant Researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koDepressantes_ES
dc.subject.koSedativees_ES
dc.subject.koAcuyoes_ES
dc.subject.koHierba santaes_ES
dc.subject.koAnalgesices_ES
dc.subject.koAntianxiety.es_ES
dc.titleNeuropharmacological studies of Piper auritum Kunth (Piperaceae): antinociceptive and anxiolytic-like effectses_ES
dc.typeartículoes_ES

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