Mechanism of action and potential use of tamoxifen in the treatment of acute mania

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dc.contributor.affiliationPostgraduate training in Psychiatry, Instituto Jaliscience de Salud Mental, Guadalajara Jalisco, México
dc.contributor.emailmonica.flores@imp.edu.mx; flores_ramos@hotmail.com.mx
dc.creatorLedezma-Acevedo, Jessicaes_ES
dc.creatorFlores-Ramos, Mónicaes_ES
dc.creatorCarvajal-Lohr, Armandoes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.date2015
dc.date.accessioned2025-11-20T15:41:44Z
dc.date.accessioned2026-03-27T15:33:54Z
dc.date.available2025-11-20T15:41:44Z
dc.date.issued2015
dc.date.published2015
dc.descriptionBackground: Bipolar Disorder is a psychiatric condition highly disabling, with elevated rates of psychiatric and medical comorbidities that contribute substantially to morbidity and mortality. Pathophysiology of the illness is not well known but recent biologic and pharmacological studies suggest that altered receptor-mediated signal transduction mechanisms contribute to the pathophysiology of the disease. Accordingly, medications with effect in these signal transduction mechanisms are supposed to be useful in the treatment of Bipolar Disorder, such is the case of tamoxifen. Animal model studies and clinical trials have been conducted to address the efficacy and side-effect profile of tamoxifen. Objective: In this review we take a closer look to some of the findings regarding the potential role of tamoxifen in the treatment of patients with Bipolar Disorder. Method: We conducted a systematic literature search on PubMed looking for studies that used tamoxifen for the treatment of Bipolar Disorder. Results: A limited number of clinical studies concerning the effect of tamoxifen as a treatment in Bipolar patients were identified. Conclusion: Mechanism of action of tamoxifen suggests that it could be useful in patients with manic episodes; however more evidence is desirable to evaluate the efficacy of tamoxifen in different clinical profiles of patients with bipolar disorder.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.2174/2211556004666151008214355
dc.identifier.eissn2211-5579
dc.identifier.issn2211-5560
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEmiratos Árabes Unidos
dc.identifier.urihttp://doi.org/10.2174/2211556004666151008214355
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8509
dc.language.isoenges_ES
dc.publisherBentham Sciencees_ES
dc.relation4(2):76-83
dc.relation.jnabreviadoCURR PSYCHOPHARMACOL
dc.relation.journalCurrent Psychopharmacology
dc.rightsAcceso Cerradoes_ES
dc.subject.kwBipolar disorder
dc.subject.kwManic episode
dc.subject.kwTamoxifen
dc.subject.kwProtein kinase c
dc.subject.kwSelective estrogen receptor modulators
dc.titleMechanism of action and potential use of tamoxifen in the treatment of acute maniaes_ES
dc.typeArtículoes_ES

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