Antidepressant effects of acupoint stimulation and fluoxetine by increasing dendritic arborization and spine density in CA1 hippocampal neurons of socially isolated rats

Simple item page
dc.contributor.affiliationDepartamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, 11340, Mexico
dc.contributor.emailramirezsanjuan@me.com (E. Ramírez-San Juan)
dc.creatorDávila-Hernández, Amalia
dc.creatorZamudio, Sergio R.
dc.creatorMartínez-Mota, Lucía
dc.creatorGonzález-González, Roberto
dc.creatorRamírez-San Juan, Eduardo
dc.date2018
dc.date.accessioned2026-07-01T21:13:56Z
dc.date.issued2018
dc.date.published2018
dc.descriptionGiven the importance of depression and the adverse effects of conventional treatment, it is necessary to seek complementary therapies. In a rat model of depression, this study aimed to assess the behavioral and morphological effects of embedding absorbable thread in acupoints (acu-catgut), and compare the results to those of fluoxetine treatment and the corresponding control groups. Therefore, depressive-like behavior was evaluated with the forced swimming test, and dendritic morphology (in the CA1 hippocampal region) with the Golgi-Cox technique and Sholl analysis. After weaning, male Sprague-Dawley rats were housed in social isolation for 8 weeks to induce depressive-like behavior. They were then given a 21-day treatment by stimulating acupoints with acu-catgut (AC) or fluoxetine (FX) (2 mg/kg). Rats were divided into six groups: Control (socially housed), social isolation (SI), SI + AC, SI + Sham (sham embedding of thread), SI + FX and SI + VH (vehicle). Compared to fluoxetine, acu-catgut treatment was more effective in reversing depressive-like behavior elicited by SI. The SI-induced reduction in dendritic length and spine density in hippocampal CA1 pyramidal neurons was attenuated after prolonged treatment with acu-catgut or fluoxetine. Hence, both treatments proved capable of reversing depressive-like alterations caused by SI, likely due to dendritic remodeling in the hippocampus.
dc.formatPDF
dc.identifierJC18NC18
dc.identifier.doi10.1016/j.neulet.2018.03.057
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeIrlanda
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/170
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2018.03.057
dc.language.isoeng
dc.publisherElsevier
dc.relation675:48-53
dc.relation.jnabreviadoNEUROSCI LETT
dc.relation.journalNeuroscience Letters
dc.rightsAcceso Cerrado
dc.subject.kwAcupuncture
dc.subject.kwCatgut
dc.subject.kwDepression
dc.subject.kwHippocampus
dc.subject.kwSocial isolation
dc.subject.kwFluoxetine
dc.titleAntidepressant effects of acupoint stimulation and fluoxetine by increasing dendritic arborization and spine density in CA1 hippocampal neurons of socially isolated rats
dc.typeArtículo

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista