Association of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: an exploratory study

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dc.contributor.affiliationDepartamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
dc.contributor.emailcamare@imp.edu.mx (Beatriz Camarena-Medellin)
dc.creatorRodríguez-Ramírez, Alejandra Monserrates_ES
dc.creatorCedillo-Ríos, Valentees_ES
dc.creatorSanabrais-Jiménez, Marco Antonioes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorHernández-Muñoz, Sandraes_ES
dc.creatorOrtega-Ortíz, Hirames_ES
dc.creatorCamarena-Medellin, Beatrizes_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-9248-0472 (Rodríguez-Ramírez, Alejandra Monserrat)
dc.creator.identificadorhttps://orcid.org/0000-0002-7722-5940 (Sanabrais-Jiménez, Marco Antonio)
dc.creator.identificadorhttps://orcid.org/0000-0001-7737-501X (Camarena-Medellin, Beatriz)
dc.date2024
dc.date.accessioned2025-06-10T19:18:33Z
dc.date.accessioned2026-03-27T15:32:19Z
dc.date.available2025-06-10T19:18:33Z
dc.date.issued2024
dc.date.published2024
dc.descriptionValproate is among the most prescribed drugs for bipolar disorder; however, 87% of patients do not report full long-term treatment response (LTTR) to this medication. One of valproate's suggested mechanisms of action involves the brain-derived neurotrophic factor (BDNF), expressed in the brain areas regulating emotions, such as the prefrontal cortex. Nonetheless, data about the role of BDNF in LTTR and its implications in the structure of the dorsolateral prefrontal cortex (dlPFC) is scarce. We explore the association of BDNF variants and dorsolateral cortical thickness (CT) with LTTR to valproate in bipolar disorder type I (BDI). Twenty-eight BDI patients were genotyped for BDNF polymorphisms rs1519480, rs6265, and rs7124442, and T1-weighted 3D brain scans were acquired. LTTR to valproate was evaluated with Alda's scale. A logistic regression analysis was conducted to evaluate LTTR according to BDNF genotypes and CT. We evaluated CT differences by genotypes with analysis of covariance. LTTR was associated with BDNF rs1519480 and right dlPFC thickness. Insufficient responders with the CC genotype had thicker right dlPFC than TC and TT genotypes. Full responders reported thicker right dlPFC in TC and TT genotypes. In conclusion, different patterns of CT related to BDNF genotypes were identified, suggesting a potential biomarker of LTTR to valproate in our population.es_ES
dc.formatPDFes_ES
dc.identifierJC10IC23es_ES
dc.identifier.doi10.1002/ajmg.b.32966
dc.identifier.eissn1552-485X
dc.identifier.issn1552-4841
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1002/ajmg.b.32966
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8380
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.relation195(3):e32966
dc.relation.jnabreviadoAM J MED GENET B NEUROPSYCHIATR GENET
dc.relation.journalAmerican Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
dc.rightsAcceso Cerradoes_ES
dc.subject.kwImaging genetics
dc.subject.kwMagnetic resonance imaging
dc.subject.kwMood disorders
dc.subject.kwMood stabilizers
dc.titleAssociation of BDNF risk variant and dorsolateral cortical thickness with long-term treatment response to valproate in type I bipolar disorder: an exploratory studyes_ES
dc.typeArtículoes_ES

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