Antidepressant-like effects of a methanol extract of Leonotis nepetifolia in mice

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dc.contributor.affiliationInstituto Politécnico Nacional CNMN, Luis Enrique Erro s/n, Unidad Profesor Adolfo López Mateos, Gustavo A. Madero, México Ciudad de México
dc.contributor.emailrestrada@imp.edu.mx; estrarosa@hotmail.com (Rosa Estrada-Reyes)
dc.creatorArrieta-Báez, Danieles_ES
dc.creatorGómez-Patiño, Mayra Beatrizes_ES
dc.creatorJurado Hernández, Noées_ES
dc.creatorMayagoitia-Novales, Lilianes_ES
dc.creatorDorantes-Barrón, Ana Maríaes_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.date2022
dc.date.accessioned2025-01-07T18:19:59Z
dc.date.accessioned2026-03-27T15:31:01Z
dc.date.available2025-01-07T18:19:59Z
dc.date.issued2022
dc.date.published2022
dc.descriptionThis study evaluated the antidepressant-like effects of a methanol extract of Leonotis nepetifolia in behavioural tests in mice. Our results showed that a single administration of the extract significantly reduced immobility behaviour in the tail suspension test, while three administrations were necessary to diminish immobility behaviour in the forced swimming test. A daily dose of the extract for 28 days improved body weight gain and significantly reduced corticosterone levels of mice exposed to chronic unpredictable mild stress. Metabolic profiling of the extract revealed that nepetaefolin, methoxynepataefolin, and 7-O-β-glucoside luteolin were the main products. Acute and repeated administration of the extract produced antidepressant-like effects in animals subjected to chronic stress. Our results suggest the hypothalamus-hypophysis-adrenal axis participates in the antidepressant actions of the extract. These results show that alterations in behaviour elicited by stress can be prevented with L. nepetifolia treatment.es_ES
dc.formatPDFes_ES
dc.identifierJC35NC22es_ES
dc.identifier.doi10.1080/14786419.2022.2058939
dc.identifier.eissn1478-6427
dc.identifier.issn1478-6419
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1080/14786419.2022.2058939
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8189
dc.language.isoenges_ES
dc.publisherTaylor & Francis Health Scienceses_ES
dc.relation36(23):6170-6176
dc.relation.jnabreviadoNAT PROD RES
dc.relation.journalNatural Product Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwLeonotis nepetifolia
dc.subject.kwAntidepressant
dc.subject.kwChronic stress
dc.subject.kwNepetaefolin
dc.subject.kwMethoxynepataefolin
dc.titleAntidepressant-like effects of a methanol extract of Leonotis nepetifolia in micees_ES
dc.typeArtículoes_ES

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