Participation of Ca2+-Calmodulin-Dependent Protein Kinase II in the Antidepressant-Like Effects of Melatonin

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dc.contributor.affiliationLaboratorio de Neurofarmacología (A.M.-R., J.O.-S., J.A., L.A.C.-J., G.B.-K.), Departamento de Neurofisiología, Dirección de Investigaciones en Neurociencias (M.G.C., C.T., R.C.-G.), and Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias (R.E.-R.), Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
dc.contributor.emailbekin@inprf.gob.mx (Rosa Estrada Reyes)
dc.creatorMiranda-Riestra, Armida
dc.creatorCercós, Montserrat G.
dc.creatorTrueta, Citlali
dc.creatorOikawa-Sala, Julián
dc.creatorArgueta, Jesús
dc.creatorConstantino-Jonapa, Luis A .
dc.creatorCruz-Garduño, Ricardo
dc.creatorBenítez-King, Gloria
dc.creatorEstrada-Reyes, Rosa
dc.date2024
dc.date.accessioned2026-06-19T21:39:02Z
dc.date.issued2024
dc.date.published2024
dc.descriptionMelatonin (N-acetyl-5-methoxytryptamine) is an indoleamine secreted by the pineal gland during the dark phase of the photoperiod. Its main function is the synchronization of different body rhythms with the dark-light cycle. Research on melatonin has significantly advanced since its discovery and we now know that it has considerable significance in various physiological processes, including immunity, aging, and reproduction. Moreover, in recent years evidence of the pharmacological possibilities of melatonin has increased. Indoleamine, on the other hand, has antidepressant-like effects in rodents, which may be mediated by the activation of calcium-calmodulin-dependent kinase II (CaMKII) and are also related to the regulation of neuroplasticity processes, including neurogenesis, synaptic maintenance, and long-term potentiation. Remarkably, patients with major depression show decreased levels of circulating melatonin in plasma. This review presents evidence of the antidepressant-like effects of melatonin in preclinical models and the participation of CaMKII in these actions. CaMKII's role in cognition and memory processes, which are altered in depressive states, are part of the review, and the effects of melatonin in these processes are also reviewed. Furthermore, participation of CaMKII on structural and synaptic plasticity and the effects of melatonin are also described. Finally, the advantages of using melatonin in combination with other antidepressants such as ketamine for neuroplasticity are described. Evidence supports that CaMKII is activated by melatonin and downstream melatonin receptors and may be the common effector in the synergistic effects of melatonin with other antidepressants. SIGNIFICANCE STATEMENT: This review compiled evidence supporting that melatonin causes antidepressant-like effects in mice through calmodulin kinase II stimulation of downstream melatonin receptors as well as the participation of this enzyme in neuroplasticity, memory, and cognition. Finally, we describe evidence about the effectiveness of antidepressant-like effects of melatonin in combination with ketamine.
dc.formatPDF
dc.identifierJC18NC24
dc.identifier.doi10.1124/molpharm.124.000890
dc.identifier.eissn1521-0111
dc.identifier.issn0026-895X
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/123
dc.identifier.urihttps://doi.org/10.1124/molpharm.124.000890
dc.language.isoeng
dc.publisherElsevier
dc.relation106(3):107-116
dc.relation.jnabreviadoMOL PHARMACOL
dc.relation.journalMolecular Pharmacology
dc.rightsAcceso Cerrado
dc.titleParticipation of Ca2+-Calmodulin-Dependent Protein Kinase II in the Antidepressant-Like Effects of Melatonin
dc.typeArtículo

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