Justicia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural products

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370
dc.contributor.emailevag@imp.edu.mx (M. E. González-Trujano)
dc.contributor.emailirmafabiolad@gmail.com (F. Domínguez)
dc.contributor.emailgimena.perorte@gmail.com (G. Pérez-Ortega)
dc.contributor.emailaguipan@imp.edu.mx (M. Aguillón)
dc.contributor.emaildavmv@imp.edu.mx (D. Martínez-Vargas)
dc.contributor.emailsalmazan@imp.edu.mx (S. Almazán-Alvarado)
dc.contributor.emailadrianmc@imp.edu.mx (A. Martínez)
dc.creatorGonzález-Trujano, Ma. Evaes_ES
dc.creatorDomínguez, Fabiolaes_ES
dc.creatorPérez-Ortega, Gimenaes_ES
dc.creatorAguillón, Migueles_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.creatorAlmazán-Alvarado, Salvadores_ES
dc.creatorMartínez, Adriánes_ES
dc.date2017
dc.date.accessioned2023-11-22T18:43:37Z
dc.date.accessioned2026-03-27T15:27:24Z
dc.date.available2023-11-22T18:43:37Z
dc.date.issued2017
dc.date.published2017
dc.descriptionJusticia spicigera Schltdl. is a vegetal species traditionally used to control epilepsy, but scientific evidence is required to reinforce this activity. The aim of the study was to evaluate the anticonvulsant-like activity of J. spicigera aqueous extract (JsAE) and a bioactive compound. JsAE was assessed in a dose-response manner (30, 100 and 1000 mg/kg, i.p.) using the pentylenetetrazol (PTZ)-induced seizures and maximal electroshock seizure (MES) test in mice in comparison to ethosuximide (ETX, reference drug 100 mg/kg, i. p.) or phenytoin (25 mg/kg, i.p.), respectively. Then a significant dosage (1000 mg/kg, i.p.) was chosen to examine electrographic activity (EEG) in rats. Treatment groups were compared to the vehicle and ETX in the convulsive behavior alone or simultaneous to EEG after PTZ-induced seizures (80 or 35 mg/kg, i.p., mice or rats). Kaempferitrin (a flavonoid of JsAE) and ETX were administered via intracerebroventricular (i.c.v, 4th ventricle, 1mg/mL) and tested in the presence of PTZ in rats. Results confirmed that JsAE delayed the onset of seizures and reduced frequency of tonic convulsion and mortality in mice. JsAE or kaempferitrin also decreased the EEG spikes frequency and amplitude in a similar manner than EXT in rats. In conclusion, these preliminary data give evidence of the potential of J. spicigera as possible anticonvulsant as recommended in folk medicine for treating epilepsy, where kaempferitrin is suggested as a partial responsible bioactive compound.
dc.formatPDF
dc.identifierMT14NC23
dc.identifier.doi10.1016/j.biopha.2017.05.075
dc.identifier.eissn1950-6007
dc.identifier.issn0753-3322
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeFrance
dc.identifier.urihttp://dx.doi.org/10.1016/j.biopha.2017.05.075
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7833
dc.language.isoeng
dc.publisherElsevier
dc.relation.jnabreviadoBIOMED PHARMACOTHER
dc.relation.journalBiomedicine & Pharmacotherapy
dc.rightsAcceso Cerrado
dc.subject.kwElectroencephalogram
dc.subject.kwFlavonoids
dc.subject.kwJusticia spicigera
dc.subject.kwKaempferitrin
dc.subject.kwPentylenetetrazol
dc.subject.kwTraditional medicine
dc.titleJusticia spicigera Schltdl. and kaempferitrin as potential anticonvulsant natural productses_ES
dc.typeArtículo

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