Central nervous system activity of a Tabernaemontana arborea alkaloid extract involves serotonergic and opioidergic neurotransmission in murine models

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Ciudad de México 14370, Mexico
dc.contributor.emailchilpa@unam.mx (R. Reyes-Chilpa) ; saguzmangu@conahcyt.mx (S.L. Guzmán-Gutiérrez)
dc.creatorGonzález-Trujano, M. E.es_ES
dc.creatorPáez-Martínez, N.es_ES
dc.creatorKrengel, F.es_ES
dc.creatorMartínez-Vargas, D.es_ES
dc.creatorLeón-Santiago, M.es_ES
dc.creatorCruz-López, B.es_ES
dc.creatorPuentes-Guerrero, J. M.es_ES
dc.creatorDíaz-Cantón, J. K.es_ES
dc.creatorReyes-Chilpa, R.es_ES
dc.creatorGuzmán-Gutiérrez, S. L.es_ES
dc.date2023
dc.date.accessioned2025-03-21T17:33:21Z
dc.date.accessioned2026-03-27T15:31:22Z
dc.date.available2025-03-21T17:33:21Z
dc.date.issued2023
dc.date.published2023
dc.descriptionTabernaemontana arborea (Apocynaceae) is a Mexican tree species known to contain ibogan type alkaloids. This study aimed at determining central nervous system-related activities of an alkaloid extract obtained from the root bark of T. arborea. A gas chromatography-mass spectrometry (GC-MS) analysis was performed to describe the alkaloid profile of the extract. A wide dosing range (0.1 to 56.2 mg/kg) of this extract was evaluated in different murine models. Electrical brain activity was examined by electroencephalography (EEG). The extract's effects on motor coordination, ambulatory activity, and memory were analyzed based on the rotarod, open field (OFT), and object recognition tests (ORT), respectively. Antidepressant and antinociceptive activities were determined using the forced swimming test (FST) and the formalin assay, respectively. In order to elucidate the underlying mechanisms of action, the 5-HT1A receptor antagonist WAY100635 (1 mg/kg) or the opioid receptor antagonist naloxone (1 mg/kg) was included in the latter experiments. GC-MS analysis (μg/mg extract) confirmed the presence of the monoterpenoid indole alkaloids (MIAs) voacangine (207.00), ibogaine (106.33), vobasine (72.81), coronaridine (30.72), and ibogamine (24.2) as principal constituents of the extract, which exhibited dose- and receptor-dependent antidepressant (0.1 to 1 mg/kg; 5-HT1A) and antinociceptive (30 and 56.2 mg/kg; opioid) effects, without altering motor coordination, ambulatory activity, and memory. EEG indicated CNS depressant activity at high doses (30 and 56.2 mg/kg). The root bark of T. arborea contains a mixture of alkaloids that may hold therapeutic value in pain relief and the treatment of psychiatric diseases without causing neurotoxic activity at effective doses.es_ES
dc.formatPDFes_ES
dc.identifierJC27NC23es_ES
dc.identifier.doi10.1016/j.fitote.2023.105602
dc.identifier.eissn1873-6971
dc.identifier.issn0367-326X
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://doi.org/10.1016/j.fitote.2023.105602
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8262
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation169:105602
dc.relation.jnabreviadoFITOTERAPIA
dc.relation.journalFitoterapia
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAntidepressant-like activity
dc.subject.kwAntinociceptive
dc.subject.kwElectroencephalogram
dc.subject.kwMemory impairment
dc.subject.kwPreclinic
dc.subject.kwTabernaemontana
dc.titleCentral nervous system activity of a Tabernaemontana arborea alkaloid extract involves serotonergic and opioidergic neurotransmission in murine modelses_ES
dc.typeArtículoes_ES

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