Electroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice

Simple item page
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección deInvestigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de laFuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico
dc.contributor.emailevag@inprf.gob.mx (M.E. González-Trujano), davmv2@gmail.com (D. Martínez-Vargas)
dc.creatorMendoza-Madrigal, Rodrigo
dc.creatorGonzález-Trujano, María Eva
dc.creatorOnofre-Campos, Daniela
dc.creatorMoreno-Pérez, Gabriel Fernando
dc.creatorCastellanos-Mijangos, Jazmin Guadalupe
dc.creatorMartínez-Vargas, David
dc.date2024
dc.date.accessioned2026-06-16T16:50:45Z
dc.date.issued2024
dc.date.published2024
dc.descriptionSalvia amarissima Ortega is a plant used in traditional medicine to treat CNS's affections. Despite its depressant properties in anxiety and fibromyalgia, there is no scientific evidence about its capability to control seizure activity. This study aimed to investigate the effects of the S. amarissima aqueous extract (SAAE) and its metabolite amarisolide A (AMA) on the electrocorticographic (ECoG) activity. The ECoG profiles were previously and concurrently analyzed to the pentylenetetrazole (85 mg/kg, i.p.)-induced seizure behavior after thirty min of the administration of several doses of the SAAE (1, 10, 30, and 100 mg/kg, i.p.) and two doses of AMA (0.5 and 1 mg/kg, i.p.). A dosage of AMA (1 mg/kg,i.p.) was selected to explore a possible mechanism of action by using antagonists of inhibitory receptors such as GABAA (picrotoxin, 1 mg/kg, i.p.) or 5-HT1A of serotonin (WAY100635, 1 mg/kg, i.p.). Significant changes in the frequency bands and the spectral power were observed after the treatment alone. Additionally, SAAE and AMA produced significant and dose-dependent anticonvulsant effects by reducing the incidence and severity of seizures and increasing latency or survival. Both antagonists prevented the effects of AMA in the severity score of seizures and survival during the tonic-clonic seizures. In conclusion, our preclinical data support that S. amarissima possesses anticonvulsant properties, in part due to the presence of amarisolide A, mediated by different inhibitory mechanisms of action. Our scientific evidence suggests that this Salvia species and amarisolide A are potential neuroprotective alternatives to control seizures in epilepsy therapy.
dc.formatPDF
dc.identifierJC06NC24
dc.identifier.doi10.1016/j.biopha.2024.116352
dc.identifier.eissn1950-6007
dc.identifier.issn0753-3322
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeFrancia
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/110
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2024.116352
dc.language.isoeng
dc.publisherElsevier
dc.relation173:116352
dc.relation.jnabreviadoBIOMED PHARMACOTHER
dc.relation.journalBiomedicine & Pharmacotherapy
dc.rightsAcceso Cerrado
dc.subject.kwAmarisolide A
dc.subject.kwSalvia amarissima
dc.subject.kwEpilepsy
dc.subject.kwNatural products
dc.subject.kwNeuroprotection
dc.titleElectroencephalographic profile of Salvia amarissima Ortega and amarisolide A in the absence and presence of PTZ-induced seizures in mice
dc.typeArtículo

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista