Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice

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dc.contributor.affiliationLaboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatryes_ES
dc.contributor.emailgbernabe@imp.edu.mxes_ES
dc.creatorRamirez-Rodriguez, Gerardo
dc.creatorGomez-Sanchez, Ariadna
dc.creatorOrtiz-Lopez, Leonardo
dc.creator.identificador"LOOL920212HNEPRN08">Ortiz Lopez, Leonardoes_ES
dc.date.accessioned2017-06-29T03:58:07Z
dc.date.accessioned2026-03-27T14:33:20Z
dc.date.available2017-06-29T03:58:07Z
dc.date.issued2014es_ES
dc.date.published2014es_ES
dc.description.abstractotrodiomaMelatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding protein is calretinin, which exerts an essential role for adult hippocampal neurogenesis. Melatonin favors calretinin-positive neurons in the dentate gyrus (DG) of young mice but hippocampal neurogenesis and plasma levels of melatonin decrease during aging. Thus, in this study, we analyzed the impact of exogenous supplementation with melatonin in calretinin-neurons and their distribution along the dorsal-ventral DG in the hippocampus at three different time points (1, 3, or 6 months) after daily treatment with melatonin (8 mg/kg) in male Balb/C mice. We found an increase in the number of calretinin-positive neurons in the DG after treatment (>66%). Although a significant decline in the number of calretinin-neurons was found in both treated (~60.46-69.56%) and untreated mice (~68.81-70.34%) with respect to the youngest mice analyzed, melatonin still maintained higher number of cells in the DG. Also, the distribution of calretinin-neurons along the dorsal-ventral DG significantly showed more cells in the ventral-DG of mice treated with melatonin. Together, the data suggest that melatonin also acts on calretinin in the DG, supporting it as a molecule connecting calcium signaling and neuronal development.es_ES
dc.description.monthDices_ES
dc.identifier2815es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.doi10.1016/j.exger.2014.10.014es_ES
dc.identifier.eissn1873-6815es_ES
dc.identifier.issn0531-5565es_ES
dc.identifier.numero60es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion147-152es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttps://doi.org/10.1016/j.exger.2014.10.014es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4664
dc.language.isoenges_ES
dc.publisherTarrytown Ny : Elsevier Sciencees_ES
dc.relation (60) 147-152 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoEXP GERONTOLes_ES
dc.relation.journalExperimental Gerontologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAdult hippocampal neurogenesises_ES
dc.subject.koAginges_ES
dc.subject.koCalretinines_ES
dc.subject.koDentate gyruses_ES
dc.subject.koDorsal–ventrales_ES
dc.subject.koHippocampuses_ES
dc.subject.koMelatonines_ES
dc.titleMelatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C micees_ES
dc.typeartículoes_ES

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