Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de Fuente, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370 México, D.F., México; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Del. Coyoacán, C.P. 04510 México D.F., México
dc.contributor.emailevag@imp.edu.mx (M.E. González-Trujano)
dc.creatorPérez-Ortega, G.es_ES
dc.creatorGonzález-Trujano, M. E.es_ES
dc.creatorÁngeles-López, G. E.es_ES
dc.creatorBrindis, F.es_ES
dc.creatorVibrans, H.es_ES
dc.creatorReyes-Chilpa, R.es_ES
dc.date2016
dc.date.accessioned2025-09-22T18:19:55Z
dc.date.accessioned2026-03-27T15:32:39Z
dc.date.available2025-09-22T18:19:55Z
dc.date.issued2016
dc.date.published2016
dc.descriptionEthnopharmacological relevance: Morelos State is one of the most important regions of Mexico where several plant species are used in traditional medicine to influence central nervous system (CNS) activity; for example Tagetes lucida Cav. Aim of the study: To investigate the ethnobotany, phytochemistry and pharmacology of the tranquilizing properties of T. lucida aerial parts. Material and methods: Data on the medicinal uses of T. lucida were explored by interviewing healers and merchants of local markets in different regions of Morelos State by using a questionnaire. Anxiolytic and/or sedative-like responses of the T. lucida were investigated in experimental models in mice such as: open-field, exploration cylinder, hole-board, plus-maze, and the barbituric-induced hypnosis potentiation. The possible mechanism of action was explored in the presence of WAY100635 (0.32mg/kg, i.p.) and flumazenil (10mg/kg, i.p.) antagonists. A feasible active compound was isolated and identified by using conventional chromatography, including UHPLC and MS (DART) [M+H]+ techniques. Results: Interviews of healers and merchants from ten local regions of Morelos State showed that they recommended T. lucida as infusion and as tincture for several culture-bound syndromes associated with the CNS. Anxiolytic and sedative-like activities of polar extracts were corroborated in the experimental models; these effects were inhibited in the presence of 5-HT1A and GABA/BDZ receptor antagonists. Dimethylfraxetin was identified as one possible active compound. Conclusions: The results support the anxiolytic and sedative-like properties of T. lucida in traditional medicine by involving serotonergic and GABAergic neurotransmission and coumarinic constituents.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.jep.2016.01.040
dc.identifier.eissn1872-7573
dc.identifier.issn0378-8741
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeIrlanda
dc.identifier.urihttps://doi.org/10.1016/j.jep.2016.01.040
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8417
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation181:221-228
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAnxiety
dc.subject.kwCentral nervoussystem
dc.subject.kwCoumarins
dc.subject.kwEthnobotany
dc.subject.kwSedative
dc.subject.kwTageteslucida
dc.titleTagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing propertieses_ES
dc.typeArtículoes_ES

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