Effect of low doses of dexamethasone on experimental pulmonary tuberculosis

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dc.contributor.affiliationSección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Domínguez Sección 16, Tlalpan, Mexico City 14080, Mexico
dc.contributor.emaillusenbeve@imp.edu.mx (E.B.-V.); rogelio.hernandezp@incmnsz.mx (R.H.-P.)
dc.creatorLara-Espinosa, Jacqueline V.es_ES
dc.creatorArce-Aceves, María Fernandaes_ES
dc.creatorBarrios-Payán, Jorgees_ES
dc.creatorMata-Espinosa, Dulcees_ES
dc.creatorLozano-Ordaz, Vasties_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorPonce-Regalado, María Doloreses_ES
dc.creatorHernández-Pando, Rogelioes_ES
dc.creator.identificadorhttps://orcid.org/0000-0001-6635-2939 (Lara-Espinosa, Jacqueline V.)
dc.creator.identificadorhttps://orcid.org/0000-0002-5134-5573 (Barrios-Payán, Jorge)
dc.creator.identificadorhttps://orcid.org/0000-0001-7210-9775 (Becerril-Villanueva, Enrique)
dc.creator.identificadorhttps://orcid.org/0000-0003-1292-3833 (Hernández-Pando, Rogelio)
dc.date2023
dc.date.accessioned2025-03-25T17:26:42Z
dc.date.accessioned2026-03-27T15:31:25Z
dc.date.available2025-03-25T17:26:42Z
dc.date.issued2023
dc.date.published2023
dc.descriptionTuberculosis (TB) is the deadliest disease caused by a bacterial agent. Glucocorticoids (GCs) have a typical anti-inflammatory effect, but recently it has been shown that they can present proinflammatory activity, mainly by increasing molecules from innate immunity. In the current study, we evaluated the effect of low doses of dexamethasone on Mycobacterium tuberculosis in vivo and in vitro. We used an established mice model of progressing tuberculosis (TB) in the in vivo studies. Intratracheal or intranasal dexamethasone therapy administered with conventional antibiotics in the late stage of the disease decreased the lung bacilli load and lung pneumonia, and increased the survival of the animals. Finally, the treatment decreased the inflammatory response in the SNC and, therefore, sickness behavior and neurological abnormalities in the infected animals. In the in vitro experiments, we used a cell line of murine alveolar macrophages infected with Mtb. Low-dose dexamethasone treatment increased the clearance capacity of Mtb by MHS macrophages, MIP-1α, and TLR2 expression, decreased proinflammatory and anti-inflammatory cytokines, and induced apoptosis, a molecular process that contributes to the control of the mycobacteria. In conclusion, the administration of low doses of dexamethasone represents a promising adjuvant treatment for pulmonary TB.es_ES
dc.formatPDFes_ES
dc.identifierJC11NC23es_ES
dc.identifier.doi10.3390/microorganisms11061554
dc.identifier.eissn2076-2607
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/microorganisms11061554
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8269
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relation11(6):1554
dc.relation.jnabreviadoMICROORGANISMS
dc.relation.journalMicroorganisms
dc.rightsAcceso Cerradoes_ES
dc.subject.kwTuberculosis
dc.subject.kwGlucocorticoids
dc.subject.kwDexamethasone
dc.subject.kwLung
dc.subject.kwApoptosis
dc.titleEffect of low doses of dexamethasone on experimental pulmonary tuberculosises_ES
dc.typeArtículoes_ES

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