The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition

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dc.contributor.affiliationDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, MOR., Mexicoes_ES
dc.contributor.emailjoseph@ibt.unam.mxes_ES
dc.creatorGutiérrez-Mariscal, Mariana
dc.creatorSánchez, Edith
dc.creatorRebolledo-Solleiro, Daniela
dc.creatorGarcía-Vázquez, Arlene Iskra
dc.creatorCote-Vélez, Antonieta
dc.creatorAcasuso-Rivero, Cristina
dc.creatorCharli, Jean-Louis
dc.creatorJoseph-Bravo, Patricia
dc.creator.identificador"GUMM781217MDFTRR01">Gutiérrez Mariscal, Marianaes_ES
dc.date.accessioned2017-06-30T03:41:33Z
dc.date.accessioned2026-03-27T14:50:53Z
dc.date.available2017-06-30T03:41:33Z
dc.date.issued2012es_ES
dc.date.published2012es_ES
dc.description.abstractotrodiomaCentral administration of thyrotropin releasing hormone (TRH) reduces anxiety; amygdalar TRH expression is inversely proportional to the anxious behavior displayed in the elevated plus maze performed during the dark phase (EPM-D). To better understand the role of TRH in amygdala function, we evaluated the expression of TRH and the elements involved in its transmission in various stressful paradigms and how they associated with behavior. Wistar male rats were exposed to restraint (RES), EPM, or the open field test (OFT) and sacrificed 0–60 min afterwards; OFT, RES and EPM were performed during the light (L), and OFT during the dark phase. Restraint increased amygdalar levels of proCRH mRNA, without change in proTRH. All paradigms augmented corticosterone release, highest after OFT-L that also enhanced proCRH mRNA levels and decreased those of proTRH.OFT-D activated the TRHsystem. Levels of anxiety or locomotion were similar in animals tested in light or dark phases but their associationwith biochemical parameters differed. ProTRHexpression and TRHrelease correlated positively with decreased anxiety in EPM-L and in OFT-D. No association with anxiety was detected in OFT-L where proCRH and proTRH expression correlatedwith locomotion supporting their involvement in arousal. The responses of TRH amygdalar systems appeared modulated by the extent of the stress response and by the circadian conditions. Increased proTRHexpression of animals exposed to OFT-Dwas specifically observed in the cortical nucleus of the amygdala, area involved in processing fear stimuli; these TRH neuronsmay thus be part of a circuit with anxiolytic propertieses_ES
dc.description.monthMayes_ES
dc.identifier2105es_ES
dc.identifier.citationMaría Teresa Cordero Ortízes_ES
dc.identifier.doi10.1016/j.brainres.2012.02.071es_ES
dc.identifier.eissn1872-6240es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion73-84es_ES
dc.identifier.placePaises bajoses_ES
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2012.02.071es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6764
dc.identifier.volumen1452es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation1452, 73-84 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain Researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koTRHes_ES
dc.subject.koCRHes_ES
dc.subject.koStresses_ES
dc.subject.koAnxietyes_ES
dc.subject.koCortical amygdalaes_ES
dc.subject.koCircadianes_ES
dc.subject.koLocomotiones_ES
dc.subject.koOpen fieldes_ES
dc.subject.koElevated plus mazees_ES
dc.subject.koRestraintes_ES
dc.subject.koCorticosteronees_ES
dc.subject.kwHormona liberadora de tirotropina (HLT)es_ES
dc.subject.kwHormona liberadora de corticotropina (HLC)es_ES
dc.subject.kwEstréses_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwAmígdala corticales_ES
dc.subject.kwCircadianoes_ES
dc.subject.kwLocomociónes_ES
dc.subject.kwCampo abiertoes_ES
dc.subject.kwLaberinto plus elevadoes_ES
dc.subject.kwRestricciónes_ES
dc.subject.kwCorticosteronaes_ES
dc.subject.meshmAmygdala-Metabolismes_ES
dc.subject.meshmAnimals Circadian Rhythm-Physiologyes_ES
dc.subject.meshmCorticosterone-Bloodes_ES
dc.subject.meshmCorticotropin-Releasing Hormone-Metabolismes_ES
dc.subject.meshmHypothalamo-Hypophyseal System-Metabolismes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmNeurons-Metabolismes_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Wistares_ES
dc.subject.meshmReceptors, Glucocorticoid-Metabolismes_ES
dc.subject.meshmRestraint, Physicales_ES
dc.subject.meshmStress, Psychological-Metabolismes_ES
dc.subject.meshmThyrotropin-Releasing Hormone-Metabolismes_ES
dc.titleThe acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian conditiones_ES
dc.typearticlees_ES

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