Flumazenil blocks the anxiolytic action of allopregnanolone

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dc.contributor.affiliationSección de Terapéutica Experimental, Departmento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., Mexicoes_ES
dc.creatorFernández-Guasti, Alonso
dc.creatorPicazo, Ofir
dc.creator.identificador"FEGA571030HDFRSL07">Fernández Guasti, José Alonsoes_ES
dc.date.accessioned2017-06-29T04:18:26Z
dc.date.accessioned2026-03-27T14:35:15Z
dc.date.available2017-06-29T04:18:26Z
dc.date.issued1995es_ES
dc.date.published1995es_ES
dc.description.abstractotrodiomaIn the burying behaviour test allopregnanolone (0.5 mg-rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg-kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone. No scheme modified the ambulatory behaviour, thus suggesting that the effect of these treatments was selective on experimental anxiety. These results indicate that the anxiolytic actions of neurosteroids are most likely mediated via the stimulation of GABAA receptors. Data are discussed on the basis of such relationshipses_ES
dc.description.monthJules_ES
dc.identifier205es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/0014-2999(95)00311-8es_ES
dc.identifier.eissn18790712es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion113-115es_ES
dc.identifier.placePaíses Bajoses_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0014-2999(95)00311-8es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4899
dc.identifier.volumen281es_ES
dc.language.isofraes_ES
dc.relation281 (1) 113-115 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.koAnxiety-Drug therapyes_ES
dc.subject.koBehavior, Animal-Drug effectses_ES
dc.subject.koDrug Interactionses_ES
dc.subject.koFemalees_ES
dc.subject.koFlumazenil-Pharmacologyes_ES
dc.subject.koGABA Modulators-Pharmacologyes_ES
dc.subject.koPregnanolone-Antagonists & inhibitorses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koGABA Modulatorses_ES
dc.subject.koPregnanolonees_ES
dc.subject.koFlumazeniles_ES
dc.titleFlumazenil blocks the anxiolytic action of allopregnanolonees_ES
dc.typearticlees_ES

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