Supplementation with a Symbiotic Induced Neuroprotection and Improved Memory in Rats with Ischemic Stroke

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dc.contributor.affiliationCentro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Campus Norte, Huixquilucan CP 52786, Edo. de México, Mexico.
dc.contributor.emailjose.ibarra@anahuac.mx
dc.creatorCruz-Martínez, Yolanda
dc.creatorAguilar-Ponce, Leslie
dc.creatorRomo-Araiza, Alejandra
dc.creatorChávez-Guerra, Almudena
dc.creatorMartiñón, Susana
dc.creatorIbarra-García, Andrea P.
dc.creatorArias-Santiago, Stella
dc.creatorGálvez-Susano, Vanessa
dc.creatorIbarra, Antonio
dc.date2024
dc.date.accessioned2026-06-25T19:03:26Z
dc.date.issued2024
dc.date.published2024
dc.descriptionAfter an ischemic stroke, various harmful mechanisms contribute to tissue damage, including the inflammatory response. The increase in pro-inflammatory cytokines has been related to greater damage to the neural tissue and the promotion of neurological alterations, including cognitive impairment. Recent research has shown that the use of prebiotics and/or probiotics counteracts inflammation and improves cognitive function through the production of growth factors, such as brain-derived neurotrophic factor (BDNF), by reducing inflammatory molecules. Therefore, in this study, the effect of the symbiotic inulin and Enterococcus faecium on neuroprotection and memory improvement was evaluated in a rat model of transient middle cerebral artery occlusion (tMCAO). In order to accomplish this, the animals were subjected to ischemia; the experimental group was supplemented with the symbiotic and the control group with the vehicle. The neurological deficit as well as spatial and working memory were evaluated using the Zea Longa scale, Morris water maze, and the eight-arm maze tests, respectively. Infarct size, the levels of BDNF, and tumor necrosis factor-alpha (TNF-α) were also assessed. The results show that supplementation with the symbiotic significantly diminished the neurological deficit and infarct size, improved memory and learning, increased BDNF expression, and reduced TNF-α production. These findings provide new evidence about the therapeutic use of symbiotics for ischemic stroke and open up the possibilities for the design of further studies.
dc.formatPDF
dc.identifierOE25IC2025
dc.identifier.doi10.3390/biomedicines12010209
dc.identifier.eissn2227-9059
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/142
dc.identifier.urihttps://doi.org/10.3390/biomedicines12010209
dc.language.isoeng
dc.publisherMDPI
dc.relation17;12(1):209
dc.relation.jnabreviadoBIOMEDICINES
dc.relation.journalBiomedicines
dc.rightsAcceso Cerrado
dc.subject.kwBDNF
dc.subject.kwEnterococcus faecium
dc.subject.kwTNF-α
dc.subject.kwCerebral ischemia
dc.subject.kwCognitive impairment
dc.subject.kwCytokines
dc.subject.kwMemory
dc.subject.kwNeuroprotection
dc.subject.kwSymbiotic
dc.subject.kwTMCAO
dc.titleSupplementation with a Symbiotic Induced Neuroprotection and Improved Memory in Rats with Ischemic Stroke
dc.typeArticulo

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