Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract

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dc.contributor.affiliationInstituto de Química, Universidad Nacional Autónoma de Mexico, Coyoacán, Mexico D.F. 04510, Méxicoes_ES
dc.contributor.emailrestrada@imp.edu.mxes_ES
dc.contributor.emailestrarosa@hotmail.comes_ES
dc.creatorMartínez-Vázquez, M.
dc.creatorEstrada-Reyes, R.
dc.creatorMartínez-Laurrabaquio, A.
dc.creatorLópez-Rubalcava, C.
dc.creatorHeinze, G.
dc.date.accessioned2017-06-29T06:10:04Z
dc.date.accessioned2026-03-27T14:36:48Z
dc.date.available2017-06-29T06:10:04Z
dc.date.issued2012es_ES
dc.date.published2012es_ES
dc.description.abstractotrodiomaEthnopharmacological relevance: Dracocephalum moldavica is used as a tranquilizer and as remedy for nervous conditions relief in the Mexican traditional medicine. Despite its intensive use no literature reported neuropharmacological studies on Dracocephalum moldavica as yet. Aim of the study: The sedative, anxiolytic-like and antidepressant-like effects of the aqueous extract of aerial parts of Dracocephalum moldavica (Lamiaceae) (DM) were evaluated in behavioral models in mice. The general toxic effects of DM were evaluated as well as their chemical analysis was performed. Materials and methods: DM effects were evaluated on pentobarbital-induced sleeping time (SPT), the hole-board (HBT), and the avoidance exploratory behavior (AEBT) tests and on the forced swimming test (FST). General activity and motor coordination were evaluated in the open field (OFT) and Rota-rod tests, respectively. The acute toxicity of DM was determinate by its LD50 dose. The chemical analyses DM were performed by chromatographic and HPLC–ESI-MS techniques. Results: DM prolonged the pentobarbital-induced sleeping time, induced sedation in the HBT, decreased spontaneous activity and produced motor coordination impairment in mice. However, DM did not show anxiolytic effects in the AEBT or HBT and it was not effective in FST. The DM-treatment produced mortalities with LD50 = 470 mg-kg body weight. The HPLC–ESI-MS analysis of DM revealed that (acacetin, apigenin and luteolin)-7-O-_-D-(6’-O-malonyl)-glucoside derivates are the main compounds of DM. Conclusions: DM induced sedative actions and a general inhibition of CNS activity observed by the decrease of animals’ general activity, motor coordination and exploration.es_ES
dc.description.monthJunes_ES
dc.identifier714es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.doi10.1016/j.jep.2012.03.028es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.numero3es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion908-917es_ES
dc.identifier.placeLimerickes_ES
dc.identifier.urihttps://doi.org/10.1016/j.jep.2012.03.028es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/5398
dc.identifier.volumen141es_ES
dc.language.isoenges_ES
dc.relation141 (3) 908-917 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnxietyes_ES
dc.subject.koSedativeses_ES
dc.subject.koForeign hyssopes_ES
dc.subject.koToronjil azules_ES
dc.subject.koFlavonoidses_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwSedanteses_ES
dc.subject.kwToronjil azules_ES
dc.subject.kwForeign hyssopes_ES
dc.subject.kwFlavonoideses_ES
dc.titleNeuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extractes_ES
dc.typearticlees_ES

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