Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats

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dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Sede Sur, Mexico
dc.contributor.emailevag@imp.edu.mx (Ma. Eva González-Trujano)
dc.creatorHernandez-Leon, A.es_ES
dc.creatorFernández-Guasti, A.es_ES
dc.creatorGonzález-Trujano, M. E.es_ES
dc.date2016
dc.date.accessioned2025-09-22T19:13:48Z
dc.date.accessioned2026-03-27T15:32:40Z
dc.date.available2025-09-22T19:13:48Z
dc.date.issued2016
dc.date.published2016
dc.descriptionBackground: Rutin is a bioflavonoid found in fruits, vegetables and plants used in traditional medicine to alleviate pain. However, rutin's scientific evidence for the modulation of pain and its mechanism of action is lacking. It is well known that the periaqueductal grey matter (PAG) contains opioidergic neural circuits involved in the modulation of descending nociception. The aim of this study was to investigate if antinociceptive activity of rutin is modulated by the PAG circuitry involving participation of opioid receptors. Methods: The experimental design included groups of rats receiving rutin systemically (30-1000 mg/kg) or microinjected into the vlPAG (8-32 nmol/4 μL) alone or in the presence of an opioid antagonist, naltrexone (5 mg/kg, i.p. or 26 nmol/4 μL, respectively). Nociception was assessed using the formalin test and compared versus the reference drugs, tramadol and morphine. Results: Systemic or intra-vlPAG administration of rutin significantly decreased both phases of the formalin test. Antinociceptive responses of the reference drugs were prevented by naltrexone, whereas the antinociceptive effect of rutin was inhibited by this antagonist mainly in the phase II of the formalin test. Conclusions: Our results provide evidence that rutin produces antinociceptive effects involving central modulation of the vlPAG descending circuit partly mediated by an opioidergic mechanism.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1002/ejp.720
dc.identifier.eissn1532-2149
dc.identifier.issn1090-3801
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1002/ejp.720
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8418
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation20(2):274-83
dc.relation.jnabreviadoEUR J PAIN
dc.relation.journalEuropean Journal of Pain
dc.rightsAcceso Cerradoes_ES
dc.titleRutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in ratses_ES
dc.typeArtículoes_ES

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