Role of mu and delta opioid receptors in alcohol drinking behaviour

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dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente, Subdirección de Investigaciones Clínicases_ES
dc.creatorMéndez, M.
dc.creatorMorales-Mulia, M.
dc.creator.identificador"MEUM570510MDFNBL05">Méndez Ubach, Milagroses_ES
dc.date.accessioned2017-06-30T04:02:19Z
dc.date.accessioned2026-03-27T15:24:45Z
dc.date.available2017-06-30T04:02:19Z
dc.date.issued2008es_ES
dc.date.published2008es_ES
dc.description.abstractotrodiomaThe dopaminergic mesolimbic system plays a key role in the mechanisms of reinforcement elicited by alcohol (ethanol) and other drugs of abuse. Numerous lines of evidence indicate that ethanol reinforcement mechanisms involve, at least partially, the ethanol-induced activation of the endogenous opioid system. Ethanol may alter opioidergic transmission at different levels, including the biosynthesis, release, and degradation of opioid peptides, as well as binding of endogenous ligands to opioid receptors. Several studies suggest that mu and delta opioid receptors play a major role in ethanol reinforcement and dependence. These studies implicate enkephalins and beta-endorphin as physiological mediators of ethanol's actions in the brain. In this review we describe the pharmacological characteristics of opioid receptors and their distribution in brain, as well as the major functions of their endogenous ligands. Thereafter, we present evidence supporting the participation of mu and delta opioid receptors in ethanol reinforcement mechanisms and high alcohol drinking behaviour. The use of opioid receptor agonists and antagonists, as well as ethanol-preferring selected rodents and knockout mice, has contributed to understand the role of mu and delta receptors in these processes. The effects of ethanol on binding of selective ligands to opioid receptors in different experimental models are also reviewed. The relevance of opioid receptors in human alcoholism is further evidenced by the association of mu receptor polymorphisms with ethanol dependence. The clinical implication of these findings is discussed regarding the differential responses observed in some alcoholic patients to treatment with opioid receptor antagonists such as naltrexone.es_ES
dc.description.monthJunes_ES
dc.identifier2466es_ES
dc.identifier.citationJosé Artemio Hernández Martínezes_ES
dc.identifier.eissn1874-4745es_ES
dc.identifier.issn1874-4737es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion239-252es_ES
dc.identifier.placeEmiratos Árabes Unidoses_ES
dc.identifier.urihttp://doi.org/10.2174/1874473710801020239es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7107
dc.identifier.volumen1es_ES
dc.language.isoenges_ES
dc.relation1 (2) 239-252 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoCURR DRUG ABUSE REVes_ES
dc.relation.journalCurrent Drug Abuse Reviewses_ES
dc.rightsacceso cerradoes_ES
dc.titleRole of mu and delta opioid receptors in alcohol drinking behavioures_ES
dc.typearticlees_ES

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