Aqueous extract of pomegranate enriched in ellagitannins prevents anxiety-like behavior and metabolic changes induced by cafeteria diet in an animal model of menopause

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dc.contributor.affiliationLaboratorio de Neuropsicofarmacología. Dirección de Neurociencias. Instituto Nacional de Psiquiatría "Ramón de la Fuente", Mexico City, Mexico
dc.contributor.emailestrada@imp.edu.mx (Estrada-Camarena E.)
dc.creatorEstrada-Camarena, E. M.es_ES
dc.creatorLópez-Rubalcava, C.es_ES
dc.creatorRamírez-Rodríguez, G. B.es_ES
dc.creatorPulido, D.es_ES
dc.creatorCervantes-Ayala, N.es_ES
dc.creatorAzpilcueta-Morales, G.es_ES
dc.creatorGranados-Juárez, A.es_ES
dc.creatorVega-Rivera, N. M.es_ES
dc.creatorIslas-Preciado, D.es_ES
dc.creatorTreviño, S.es_ES
dc.creatorGortari, P. dees_ES
dc.creatorGonzález-Trujano, M. E.es_ES
dc.creatorGarcía-Viguera, C.es_ES
dc.date2020
dc.date.accessioned2023-05-26T17:07:17Z
dc.date.accessioned2026-03-27T15:26:09Z
dc.date.available2023-05-26T17:07:17Z
dc.date.issued2020
dc.date.published2020
dc.descriptionWomen around menopause are vulnerable to present psychiatric and metabolic disorders; thus, therapies that contribute to treat both pathologies are required. Previous reports showed that an aqueous extract of pomegranate (Punica granatum), enriched in ellagitannins, exerts an antidepressant-like effect in ovariectomized rats. We analyze whether this aqueous extract of P. granatum (AE-PG) prevents the anxiety-like behavior induced by a cafeteria diet (CAF) in middle-aged ovariectomized rats at the same time that it prevents an increase in body weight, glucose, lipids, and the changes on mRNA expression of the peroxisome proliferator-activated receptor-gamma (PPAR-γ) in the liver. Also, the effects of AE-PG on the protein levels of PPAR-γphospho-PPAR-γ, extracellular signal-regulated protein kinase (ERK1/2) and phospho-ERK1/2 were measured in the hippocampus and amygdala. CAF induced anxiety-like behavior, augmented lipids and glucose blood levels, body weight, visceral fat, insulin resistance, and decreased mRNA expression of PPAR-γ in the liver. In rats fed with the CAF, AE-PG prevented the anxiety-like behavior, reduced body weight, lowered lipid levels, reduced insulin resistance, and increased PPAR-γ mRNA expression in the liver. In the hippocampus, ERK1/2 but not PPAR-γ protein levels were decreased by CAF, while AE-PG prevented these effects. In the amygdala, CAF increased the phosphorylation of PPARγ, and AE-PG prevented it. In contrast, AE-PG rescued the decreased ERK1/2 protein level in the hippocampus caused by CAF. In conclusion, AE-PG treatment prevented anxiogenic and metabolic effects induced by CAF, and its effects appear to be mediated by ERK1/2 and PPARγ depending on the brain area studied.es_ES
dc.formatPDFes_ES
dc.identifierJC09NC20es_ES
dc.identifier.doi10.1016/j.neuint.2020.104876
dc.identifier.eissn1872-9754
dc.identifier.issn0197-0186
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1016/j.neuint.2020.104876
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7697
dc.language.isoenges_ES
dc.publisherPergamon Presses_ES
dc.relation141:104876
dc.relation.jnabreviadoNEUROCHEM INT
dc.relation.journalNeurochemistry International
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAmygdala
dc.subject.kwAnxiety
dc.subject.kwCafeteria diet
dc.subject.kwInsulin resistance
dc.subject.kwMenopause
dc.subject.kwPeroxisome proliferator-activated receptor-gamma
dc.subject.kwPomegranate
dc.titleAqueous extract of pomegranate enriched in ellagitannins prevents anxiety-like behavior and metabolic changes induced by cafeteria diet in an animal model of menopausees_ES
dc.typeArtículoes_ES

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