Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins

Simple item page
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente, México, D. F., Méxicoes_ES
dc.contributor.emailpedromiguel.menaparreno@unipr.ites_ES
dc.creatorGonzález-Trujano, María Eva
dc.creatorPellicer, Francisco
dc.creatorMena, Pedro
dc.creatorMoreno, Diego A.
dc.creatorGarcía-Viguera, Cristina
dc.creator.identificadorGOTE681027MMCNRV09>Gonzalez Trujano, Maria Evaes_ES
dc.date.accessioned2017-06-29T03:41:40Z
dc.date.accessioned2026-03-27T14:33:38Z
dc.date.available2017-06-29T03:41:40Z
dc.date.issued2015es_ES
dc.date.published2015es_ES
dc.description.abstractotrodiomaPomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory propertieses_ES
dc.identifier2546es_ES
dc.identifier.citationElizabeth Cuesta Hernándezes_ES
dc.identifier.doi10.3109/09637486.2015.1024208es_ES
dc.identifier.eissn1465-3478es_ES
dc.identifier.issn0963-7486es_ES
dc.identifier.numero4es_ES
dc.identifier.paginacion395-399es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttps://doi.org/10.3109/09637486.2015.1024208es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4395
dc.identifier.volumen66es_ES
dc.language.isoenges_ES
dc.relation66(4) 395-399p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoINT J FOOD SCI NUTRes_ES
dc.relation.journalInternational Journal of Food Sciences and Nutritiones_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnti-inflammatoryes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koAnthocyanines_ES
dc.subject.koEllagitannines_ES
dc.subject.koFormalin testes_ES
dc.subject.koGastroprotectiones_ES
dc.subject.meshAnalgesics-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Inflammatory agents-Pharmacologyes_ES
dc.subject.meshChromatography, High pressure liquides_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshHydrolyzable Tannins-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshNociceptive Pain-Drug therapyes_ES
dc.subject.meshPlant Extracts-Pharmacologyes_ES
dc.subject.meshPolyphenols-Pharmacologyes_ES
dc.subject.meshPunicaceaees_ES
dc.titleAntinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitanninses_ES
dc.typeartículoes_ES

Files

Collections

Artículos de revista