Study of minor physical anomalies in complete nuclear mexican families. Evidence of neurodevelopmental problems in schizophrenia

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dc.contributor.affiliationHospital Psiquiátrico Fray Bernardino Álvarez, Mexico City, Mexico
dc.contributor.emailfambrosiog@hotmail.com (Félix Ambrosio-Gallardo)
dc.creatorAmbrosio-Gallardo, Félixes_ES
dc.creatorCruz-Fuentes, Carloses_ES
dc.creatorHeinze-Martin, Gerhardes_ES
dc.creatorCaraveo-Anduaga, Jorgees_ES
dc.creatorCortés-Sotres, Josées_ES
dc.date2015
dc.date.accessioned2025-09-29T17:36:07Z
dc.date.accessioned2026-03-27T15:32:45Z
dc.date.available2025-09-29T17:36:07Z
dc.date.issued2015
dc.date.published2015
dc.descriptionIntroduction Minor physical anomalies (MPA) are dysmorphic features that reflect deviations in early development, are morphological variants that appear during the first trimester of pregnancy and could be used as a marker of disease risk in susceptible people. The literature agrees that the number of MPA is higher in patients with schizophrenia compared with their relatives and healthy subjects. The purpose of this study is to compare the MPA, assessed using the Gourion Scale, in complete nuclear families (families with a member with schizophrenia and control families) by determining the MPA mean, concordance and heritability for the total score on the MPA Gourion Scale for each anomaly. Method The sample consisted of 60 families with at least one schizophrenic patient (284 members) and 61 control families (249 members). Results: The mean total score for the scale was 5.72 ± 2.3 MPA in the case of families with at least one schizophrenic patient and 1.8 ± 4.46 MPA for control families. The average for families of patients without considering the patient in the analysis was 5.59 ± 2.3 MPA; for patients, the mean was 6.14 ± 2.4 MPA. In the analysis by anomaly differences were found only in eleven anomalies found no evidence of heritability or concordance. Conclusions MPA occur more frequently in patients, but a pattern of low consistency between them persists. It is concluded that MPA could be a marker of neurodevelopmental problems, but it is not suitable to consider them a Gourion scale as endophenotype.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1371/journal.pone.0117080
dc.identifier.eissn1932-6203
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0117080
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8429
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation10(1):e0117080
dc.relation.jnabreviadoPLOS ONE
dc.relation.journalPLoS One
dc.rightsAcceso Cerradoes_ES
dc.titleStudy of minor physical anomalies in complete nuclear mexican families. Evidence of neurodevelopmental problems in schizophreniaes_ES
dc.typeArtículoes_ES

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