Circadian synchronization of feeding attenuates rats' food restriction-induced anxiety and amygdalar thyrotropin-releasing hormone downregulation

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dc.contributor.affiliationLaboratorio de Neurofisiología Molecular, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México 14370, Mexico
dc.contributor.emailgortaril@inprf.edu.mx
dc.creatorSoberanes-Chávez, Paulina
dc.creatorTrujillo-Barrera, Jariz
dc.creatorGortari, Patricia de
dc.creator.identificadorhttps://orcid.org/0000-0002-9402-2061 (Gortari, Patricia de)
dc.date2024
dc.date.accessioned2026-06-16T19:50:11Z
dc.date.issued2024
dc.date.published2024
dc.descriptionAnxiety is a common comorbidity of obesity, resulting from prescribing long-term caloric restriction diets (CRDs); patients with a reduced food intake lose weight but present anxious behaviors, poor treatment adherence, and weight regain in the subsequent 5 years. Intermittent fasting (IF) restricts feeding time to 8 h during the activity phase, reducing patients' weight even with no caloric restriction; it is unknown whether an IF regime with ad libitum feeding avoids stress and anxiety development. We compared the corticosterone blood concentration between male Wistar rats fed ad libitum or calorie-restricted with all-day or IF food access after 4 weeks, along with their anxiety parameters when performing the elevated plus maze (EPM). As the amygdalar thyrotropin-releasing hormone (TRH) is believed to have anxiolytic properties, we evaluated its expression changes in association with anxiety levels. The groups formed were the following: a control which was offered food ad libitum (C-adlib) or 30% of C-adlib's energy requirements (C-CRD) all day, and IF groups provided food ad libitum (IF-adlib) or 30% of C-adlib's requirements (IF-CRD) with access from 9:00 to 17:00 h. On day 28, the rats performed the EPM and, after 30 min, were decapitated to analyze their amygdalar TRH mRNA expression by in situ hybridization and corticosterone serum levels. Interestingly, circadian feeding synchronization reduced the body weight, food intake, and animal anxiety levels in both IF groups, with ad libitum (IF-adlib) or restricted (IF-CRD) food access. The anxiety levels of the experimental groups resulted to be negatively associated with TRH expression, which supported its anxiolytic role. Therefore, the low anxiety levels induced by synchronizing feeding with the activity phase would help patients who are dieting to improve their diet therapy adherence.
dc.formatPDF
dc.identifierJC03NC24
dc.identifier.doi10.3390/ijms25115857
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/102
dc.identifier.urihttps://doi.org/10.3390/ijms25115857
dc.language.isoeng
dc.publisherMDPI
dc.relation25(11):5857
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerrado
dc.subject.kwCircadian feeding
dc.subject.kwAnxiety
dc.subject.kwTRH
dc.subject.kwIntermittent fasting
dc.subject.kwAmygdala
dc.subject.kwCorticosterone
dc.subject.kwStress
dc.titleCircadian synchronization of feeding attenuates rats' food restriction-induced anxiety and amygdalar thyrotropin-releasing hormone downregulation
dc.typeArtículo

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