Interaction between estrogens and antidepressants in the forced swimming test in rats

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dc.contributor.affiliationDepto de Farmacobiología CINVESTAV-IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, Méxicoes_ES
dc.contributor.emailestrada@imp.edu.mxes_ES
dc.creatorEstrada-Camarena, E.
dc.creatorFernández-Guasti, A.
dc.creatorLópez-Rubalcava, Carolina
dc.creator.identificador"EACE710206MVZSMR06">Estrada Camarena, Erika Monserrates_ES
dc.date.accessioned2017-06-30T01:32:04Z
dc.date.accessioned2026-03-27T14:46:56Z
dc.date.available2017-06-30T01:32:04Z
dc.date.issued2004es_ES
dc.date.published2004es_ES
dc.description.abstractotrodiomaRATIONALE: Several reports suggest that estrogens possess antidepressant effects and could facilitate the action of some antidepressants. OBJECTIVE: To analyze the interaction between three different types of estrogens, 17 beta-estradiol (E(2)), ethinylestradiol (EE(2)) or diethyl-stilbestrol (DES) and the antidepressants, fluoxetine (FLX) or desipramine (DMI) in ovariectomized female rats subjected to an animal model for the study of antidepressant compounds, the forced swimming test (FST). METHODS: The effect of the combination of a sub-optimal dose of FLX (2.5 mg-kg) or DMI (2.5 mg-kg) with a sub-active dose of E(2 )(10 microg-kg), EE(2), (2.5 or 5 microg-kg) or DES (1 mg-kg) was analyzed in both the FST and the open field paradigm. RESULTS: The combination of a sub-optimal dose of E(2) or DES with that of the antidepressant DMI resulted in a clear antidepressant-like effect, evidenced by a significant decrease in immobility accompanied by an increase in climbing behavior. Sub-optimal doses of either E(2) or DES also facilitated the antidepressant-like effect of a sub-optimal dose of FLX. In this case, a decrease in immobility with a concomitant increase in swimming behavior was observed. Finally, the combination of EE(2) with either DMI or FLX decreased immobility and induced an increase in both swimming and climbing behaviors. All combinations decreased rats' locomotor activity when evaluated in the open field test. CONCLUSION: In the FST estrogens were able to facilitate the action of two different kinds of antidepressants; however, these effects were dependent on the type of estrogen usedes_ES
dc.description.monthAbres_ES
dc.identifier1449es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1007/s00213-003-1707-4es_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.numero1-2es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion139-145es_ES
dc.identifier.placeAlemaniaes_ES
dc.identifier.urihttps://doi.org/10.1007/s00213-003-1707-4es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6130
dc.identifier.volumen173es_ES
dc.language.isoenges_ES
dc.relation173 (1-2) 139-145 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGY (BERL)es_ES
dc.relation.journalPsychopharmacology (Berl)es_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koAntidepressive Agentses_ES
dc.subject.koPharmacologyes_ES
dc.subject.koTherapeutic usees_ES
dc.subject.koBehavior, Animales_ES
dc.subject.koDepressiones_ES
dc.subject.koDrug therapyes_ES
dc.subject.koPsychologyes_ES
dc.subject.koDisease Models, Animales_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koDrug Interactionses_ES
dc.subject.koEstrogenses_ES
dc.subject.koFemalees_ES
dc.subject.koMotor Activityes_ES
dc.subject.koDrug effectses_ES
dc.subject.koOvariectomyes_ES
dc.subject.koMethodses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSwimminges_ES
dc.subject.koEstrogenses_ES
dc.subject.kwAnimaleses_ES
dc.subject.kwAgentes antidepresivoses_ES
dc.subject.kwFarmacologíaes_ES
dc.subject.kwUso terapeúticoes_ES
dc.subject.kwConducta animales_ES
dc.subject.kwDepresiónes_ES
dc.subject.kwTerapia con medicamentoses_ES
dc.subject.kwPsicologíaes_ES
dc.subject.kwModelos de enfermedad de animaleses_ES
dc.subject.kwDosis-Respuesta a Drogaes_ES
dc.subject.kwInteracciones medicamentosases_ES
dc.subject.kwEstrogenoses_ES
dc.subject.kwActividad motoraes_ES
dc.subject.kwEfectos del fármacoes_ES
dc.subject.kwOvariectomíaes_ES
dc.subject.kwMétodoses_ES
dc.subject.kwRatases_ES
dc.subject.kwRatas Wistares_ES
dc.subject.kwNataciónes_ES
dc.subject.kwEstrógenoses_ES
dc.titleInteraction between estrogens and antidepressants in the forced swimming test in ratses_ES
dc.typearticlees_ES

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