Association between IL-15 and insulin plasmatic concentrations in patients with pulmonary tuberculosis and type 2 diabetes

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dc.contributor.affiliationGraduate and Research Section, Higher School of Medicine of the National Polytechnic Institute, Mexico City, 11340, Mexico
dc.contributor.emailnnooee@gmail.com, noe.alvarado@iner.gob.mx (N. Alvarado-Vásquez)
dc.creatorSánchez-Jiménez, Roberto
dc.creatorCerón, Eduarda
dc.creatorBernal-Alcántara, Demetrio
dc.creatorCastillejos-López, Manuel
dc.creatorGonzalez-Trujano, Eva
dc.creatorNegrete-García, Maria Cristina
dc.creatorAlvarado-Vásquez, Noé
dc.date2018
dc.date.accessioned2026-06-30T20:48:57Z
dc.date.issued2018
dc.date.published2018
dc.descriptionIL-15 is part of the immune response in pulmonary tuberculosis (PTB) but amazingly, it may also induce physiological effects similar to those of insulin. We evaluated the IL-15 and insulin plasmatic levels in adults with PTB and with or without type 2 diabetes mellitus (DM2), who received previous antituberculosis therapy for at least 2 months. We analyzed the concentrations of glucose, glycated hemoglobin, insulin, as well as levels of IL-15, IL-2, IFN-γ, and TNF-α in patients with PTB, patients with PTB-DM2, household contacts with DM2 (C-DM2), and healthy household contacts (H-C). Our results showed unexpected high levels of glucose, insulin, and IL-15 in the PTB and C-DM2 groups. In comparison, low levels of these same indicators were observed in the PTB-DM2 and H-C groups. Interestingly, our analysis showed a positive correlation of IL-15 with insulin in the PTB group (r = 0.73) and in the C-DM2 group (r = 0.66). In comparison, a weak correlation between IL-15 and insulin was observed in the PTB-DM group (r = 0.10) and in the H-C group (ρ = 0.26). Our results suggest an association between IL-15 and insulin levels in the patient with PTB. Intriguingly, this association was weaker in the patient with PTB-DM2.
dc.formatPDF
dc.identifierJC16NC18
dc.identifier.doi10.1016/j.tube.2018.06.009
dc.identifier.eissn1873-281X
dc.identifier.issn1472-9792
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEscocia
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/168
dc.identifier.urihttps://doi.org/10.1016/j.tube.2018.06.009
dc.language.isoeng
dc.publisherElsevier
dc.relation111:114-120
dc.relation.jnabreviadoTUBERCULOSIS (EDINB)
dc.relation.journalTuberculosis
dc.rightsAcceso Cerrado
dc.subject.kwInterleukin-15
dc.subject.kwInsulin
dc.subject.kwCytokines
dc.subject.kwType 2 diabetes
dc.subject.kwPulmonary tuberculosis
dc.titleAssociation between IL-15 and insulin plasmatic concentrations in patients with pulmonary tuberculosis and type 2 diabetes
dc.typeArtículo

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