Aβ40 oligomers promote survival and early neuronal differentiation of dentate Gyrus-Isolated precursor cells through activation of the akt signaling pathway

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dc.contributor.affiliationLaboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, 14370, Mexico City, Mexico.
dc.contributor.emailgbernabe@imp.edu.mx (Ramírez-Rodríguez Gerardo Bernabé) mmeraz@cinvestav.mx (Meraz-Ríos Marco Antonio)
dc.creatorSilva-Lucero, María del Carmenes_ES
dc.creatorGómez-Virgilio, Lauraes_ES
dc.creatorOrtíz-López, Leonardoes_ES
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorMeraz-Ríos, Marco Antonioes_ES
dc.date2020
dc.date.accessioned2023-11-15T18:10:38Z
dc.date.accessioned2026-03-27T15:27:14Z
dc.date.available2023-11-15T18:10:38Z
dc.date.issued2020
dc.date.published2020
dc.descriptionThe amyloid beta-peptide (Aβ) is the low-abundance product of amyloid precursor protein (APP), which is produced lifelong in the healthy brain. The functional properties of Aβ40 and Aβ42 peptides have not been completely elucidated to date. Although, several studies suggest that these peptides have a number of neurotrophic and neurotoxic properties, respectively. Interestingly, low concentrations of Aβ40 and Aβ42 regulate synaptic plasticity and improve cognitive functions, whereas the accumulation of Aβ42, coupled with the effects of age, can cause dysregulation of synaptic function, as is shown in Alzheimer's disease. Additionally, several studies suggest that both peptides, Aβ40 and Aβ42, are involved in neurogenic processes; however, these results are still controversial. Moreover, existing data indicate a direct relationship between the physicochemical characteristics of the peptides and their effects. Herein, we evaluated the effect of Aβ40 oligomers on hippocampal precursor cells isolated from the dentate gyrus of adult female C57Bl6 mice (mADGPCs). To this end, mADGPCs were treated with nanomolar and micromolar range concentrations of oligomeric forms of Aβ40 for 24, 48, and 72 h to evaluate their effects on several events in the neurogenic process in vitro, including viability, proliferation, and early differentiation. The results indicate that Aβ40 favors mADGPC proliferation, survival, and neuronal differentiation following a mechanism that involves activation of the Akt signaling pathway. Thus, this study provides evidence about the positive effects of Aβ40 oligomers on the neurogenic process in adult mouse hippocampal precursor cells in vitro.es_ES
dc.formatPDFes_ES
dc.identifierJC04SIC20es_ES
dc.identifier.doi10.1007/s12640-020-00253-6
dc.identifier.eissn1476-3524
dc.identifier.issn1029-8428
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1007/s12640-020-00253-6
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7828
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation38(3):611-625
dc.relation.jnabreviadoNEUROTOX RES
dc.relation.journalNeurotoxicity Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAmyloid-beta
dc.subject.kwHippocampus
dc.subject.kwNeural precursor cells
dc.subject.kwAkt
dc.subject.kwAdult neurogenesis
dc.subject.kwAlzheimer’s disease
dc.titleAβ40 oligomers promote survival and early neuronal differentiation of dentate Gyrus-Isolated precursor cells through activation of the akt signaling pathwayes_ES
dc.typeArtículoes_ES

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