Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

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dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Investigación en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, 101. Col. San Lorenzo Huipulco, CP 14370, Mexico City, Mexico.
dc.contributor.emailmonesca71@gmail.com
dc.creatorMorelos-Santana, E.
dc.creatorIslas-Preciado, D.
dc.creatorAlcalá-Lozano, R.
dc.creatorGonzález-Olvera, J.
dc.creatorEstrada-Camarena, E.
dc.date2024
dc.date.accessioned2026-07-01T16:11:19Z
dc.date.issued2024
dc.date.published2024
dc.descriptionCocaine/crack abstinence periods have higher risk of relapse. Abstinence as initial part of the recovery process is affected by learning and memory changes that could preserve the addictive cycle. To further understand how the interruption of cocaine/crack consumption affects neurotrophin level we performed the present systematic review and meta-analysis following the PRISMA statement (number CRD42019121643). The search formula was conducted in PubMed, Web of Science, Embase, ScienceDirect, and Google Scholar databases. The inclusion criterion was cocaine use disorder in 18 to 60-year-old people, measuring at least one neurotrophin in blood before and after a controlled abstinence period. Studies without pre-post design were excluded. Five investigations had nine different reports, four of them were subjected to a meta-analysis (n = 146). GRADE risk of bias method was followed. Individual studies reported increased peripheral brain derived neurotrophic factor (BDNF) after abstinence, evidence pooled by Hedge's g showed no significant change in BDNF after abstinence. Relevant heterogeneity in the length of the abstinence period (12-32 days), last cocaine/crack consumption monitoring and blood processing were detected that could help to explain non-significant results. Further improved methods are suggested, and a potential BDNF augmentation hypothesis is proposed that, if true, would help to understand initial abstinence as a re-adaptation period influenced by neurotrophins such as the BDNF.
dc.formatPDF
dc.identifierOE27IC2025
dc.identifier.doi10.1038/s41598-024-51901-2
dc.identifier.eissn2045-2322
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/161
dc.identifier.urihttps://doi.org/10.1038/s41598-024-51901-2
dc.language.isoeng
dc.publisherNature
dc.relation16;14(1):1410
dc.relation.jnabreviadoSCI REP
dc.relation.journalScientific Reports
dc.rightsAcceso Cerrado
dc.titlePeripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis
dc.typeArticulo

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