Synergistic action of estradiol, progesterone and testosterone on rat proceptive behavior

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dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.creatorFernández-Guasti, A.
dc.creatorVega-Matuszczyk, J.
dc.creatorLarsson, K.
dc.creator.identificador"FEGA571030HDFRSL07">Fernández Guasti, José Alonsoes_ES
dc.date.accessioned2017-06-29T04:15:28Z
dc.date.accessioned2026-03-27T14:33:43Z
dc.date.available2017-06-29T04:15:28Z
dc.date.issued1991es_ES
dc.date.published1991es_ES
dc.description.abstractotrodiomaThe role of estradiol (E), progesterone (P) and testosterone (T) in the control of rat feminine sexual behavior (receptivity, proceptivity and sexual orientation) was analyzed. The action of estradiol benzoate (EB, 1.25 _g-rat _ 3 days) and P (0.5 mg-rat) was compared in ovariectomized (OVX) and ovariectomized-adrenalectomized (OVX + ADX) subjects. Administration of EB alone was followed by maximum levels of lordosis behavior and a male-directed orientation in both OVX and OVX + ADX females. A reduction in the level of proceptivity was observed in EB-treated OVX + ADX animals as compared with EB-treated OVX rats. The administration of P to OVX + ADX females resulted in an increase in proceptive behavior similar to that observed in OVX EB-treated animals. A further study analyzed the effect of combined administration of EB, P and various doses of T (30, 90 and 270 _g-rat) in OVX + ADX rats. A synergistic action of all three hormones on proceptivity was observed. Neither a further increase in lordosis nor in male-directed orientation was observed in EB-treated females after additional treatment with P or T independently or together. Finally, we studied the effect of adrenalectomy on the spontaneous onset of estrous behavior. Adrenalectomy did not modify any aspect of normal feminine sexual behavior, suggesting that the adrenals, in the presence of the ovaries, are of no critical importance for this behavior. The possible contribution of adrenal steroids to the expression of proceptivity is discussedes_ES
dc.description.monthNoves_ES
dc.identifier126es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/0031-9384(91)90429-Res_ES
dc.identifier.eissn1873-507Xes_ES
dc.identifier.issn0031-9384es_ES
dc.identifier.numero5es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion1007-1011es_ES
dc.identifier.placeEstados Unidoses_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0031-9384(91)90429-Res_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4820
dc.identifier.volumen50es_ES
dc.language.isoenges_ES
dc.relation50 (5) 1007-1011 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoPHYSIOL BEHAVes_ES
dc.relation.journalPhysiology & Behaviores_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAdrenalectomyes_ES
dc.subject.koAnimalses_ES
dc.subject.koDrug Synergismes_ES
dc.subject.koEstradiol-Pharmacologyes_ES
dc.subject.koFemalees_ES
dc.subject.koOvariectomyes_ES
dc.subject.koProgesterone-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES
dc.subject.koTestosterone-Pharmacologyes_ES
dc.subject.koEstradioles_ES
dc.subject.koProgesteronees_ES
dc.subject.koTestosteronees_ES
dc.subject.kwEstrogenes_ES
dc.subject.kwProgesteronees_ES
dc.subject.kwTestosteronees_ES
dc.subject.kwAdrenalses_ES
dc.subject.kwProceptivityes_ES
dc.subject.kwSexual preferencees_ES
dc.subject.kwLordosises_ES
dc.titleSynergistic action of estradiol, progesterone and testosterone on rat proceptive behaviores_ES
dc.typearticlees_ES

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