Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder

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dc.contributor.affiliationInst Nacl Psiquiatria Ramon Fuente, Dept Genet Psiquiatr, Mexico City 14370, DF, Mexicoes_ES
dc.contributor.emailcamare@neuroserver.imp-neuro.edu.mxes_ES
dc.creatorCamarena, Beatriz
dc.creatorRinetti, Gina
dc.creatorCruz, Carlos
dc.creatorGómez, Amalia
dc.creatorDe la Fuente, Juan R.
dc.creatorNicolini, Humberto
dc.creator.identificador"http://orcid.org/0000-0001-7737-501X">Camarena Medellín, Beatriz Elenaes_ES
dc.date.accessioned2017-06-29T04:25:06Z
dc.date.accessioned2026-03-27T14:35:26Z
dc.date.available2017-06-29T04:25:06Z
dc.date.issued2001es_ES
dc.date.published2001es_ES
dc.description.abstractotrodiomaStudies have recently reported a sexually dimorphic association between obsessive-compulsive disorder (OCD) and a polymorphism related with variations in MAO-A activity. These observations suggest the possibility of gender differences in genetic susceptibility for OCD. We thus reexamined the MAO-a/EcoRV polymorphism in a sample of 122 OCD patients and 124 healthy subjects, An excess of allele 1 in OCD females with major depression disorder was confirmed as previously reported. This difference was more strongly associated with OCD females than males in the total sample, Finally, we analyzed a sample of 51 OCD trios. Haplotype-based haplotype relative risk (HHRR) analysis of the inheritance of the MAO-A variants revealed in the female probands that 14 out of 19 transmitted the allele 1, providing significant evidence for an allelic association between OCD and MAO-A gene, In conclusion our findings may provide molecular evidence to identify a clinically meaningful gender subtype. However, an effort should be made to replicate the analysis' in larger samples of informative parents using strategies such as transmission disequilibrium test to allow definite conclusionses_ES
dc.description.monthAbres_ES
dc.identifier325es_ES
dc.identifier.citationJosé Artemio Hernández Martínezes_ES
dc.identifier.issn0148-7299es_ES
dc.identifier.numero3es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion279-282es_ES
dc.identifier.placeHobokenes_ES
dc.identifier.urihttps://doi.org/10.1002/ajmg.1323es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/5018
dc.identifier.volumen105es_ES
dc.language.isoenges_ES
dc.relation105 (3) 279-282 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoAM J MED GENETes_ES
dc.relation.journalAmerican Journal of Medical Geneticses_ES
dc.rightsacceso cerradoes_ES
dc.subject.koObsessive-compulsive disorderes_ES
dc.subject.koGender subtypees_ES
dc.subject.koMonoamine oxidase A genees_ES
dc.subject.koAssociation studieses_ES
dc.subject.kwTrastorno obsesivo compulsivoes_ES
dc.subject.kwSubtipo de Géneroes_ES
dc.subject.kwGen monoamino oxidasa Aes_ES
dc.subject.kwEstudios de asociaciónes_ES
dc.subject.meshGenetics & Heredityes_ES
dc.titleAdditional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorderes_ES
dc.typearticlees_ES

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