Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects

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dc.contributor.affiliationEscuela de Medicina, Universidad Anáhuac Querétaro, Querétaro 76246, Mexico
dc.contributor.emailiselajuarezrojop@hotmail.com (I.E.J.-R.); hnicolini@inmegen.gob.mx (H.N.)
dc.creatorVillar-Juárez, Guillermo Efrén
dc.creatorGenis-Mendoza, Alma Delia
dc.creatorMartínez-López, J. Nicolas I.
dc.creatorFresan, Ana
dc.creatorTovilla-Zaráte, Carlos Alfonso
dc.creatorNolasco-Rosales, German Alberto
dc.creatorJuárez-De la Cruz, Ghandy Isidro
dc.creatorRuiz Ramos, David
dc.creatorVillar-Soto, Mario
dc.creatorMejía-Ortiz, Paola
dc.creatorGómez Mendiola, Marlen
dc.creatorJuárez-Rojop, Isela Esther
dc.creatorNicolini, Humberto
dc.date2024
dc.date.accessioned2026-06-01T19:55:06Z
dc.date.issued2024
dc.date.published2024
dc.descriptionBackground/objectives: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in post-COVID-19 subjects. Methods: This study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. In addition, subjects with a psychiatric diagnosis were considered. Moreover, the MoCA and MMSE scales were applied. Telomere length was determined using a polymerase chain reaction, and statistical analysis was employed using ANOVA and X2 tests. Results: We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection (p ≤ 0.05). However, no association was found between LTL and cognitive impairment in the subjects post-COVID-19. Conclusions: The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition.
dc.formatPDF
dc.identifierJC29DIEP24
dc.identifier.doi10.3390/biomedicines12102296
dc.identifier.eissn2227-9059
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/45
dc.identifier.urihttps://doi.org/10.3390/biomedicines12102296
dc.language.isoeng
dc.publisherMDPI
dc.relation12(10):2296
dc.relation.jnabreviadoBIOMEDICINES
dc.relation.journalBiomedicines
dc.rightsAcceso Cerrado
dc.subject.kwTelomere length
dc.subject.kwCognitive change
dc.subject.kwPost-COVID-19
dc.subject.kwSARS-CoV-2
dc.titleExploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects
dc.typeArtículo

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