Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration

Simple item page
dc.contributor.affiliationDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts 02111, USA.es_ES
dc.contributor.emailrlechan@tuftsmedicalcenter.org.es_ES
dc.creatorSánchez, Edith
dc.creatorSingru, Praful S.
dc.creatorWittmann, Gábor
dc.creatorNouriel, Shira S.
dc.creatorBarrett, Perry
dc.creatorFekete, Csaba
dc.creatorLechan, Ronald M.
dc.creator.identificador"SAJE691113MHGNRD06">Sánchez Jaramillo, Edithes_ES
dc.date.accessioned2017-06-30T01:37:40Z
dc.date.accessioned2026-03-27T14:47:03Z
dc.date.available2017-06-30T01:37:40Z
dc.date.issued2010es_ES
dc.date.published2010es_ES
dc.description.abstractotrodiomaTo determine whether signaling through TNF and’or nuclear factor-kappaB contributes to bacterial lipopolysaccharide (LPS)-induced activation of type 2 iodothyronine deiodinase (D2) in tanycytes lining the floor and infralateral walls of the third ventricle, the effect of a TNF antagonist on D2 gene expression and LPS-induced Ikappa-Balpha expression in tanycytes were studied. Animals treated with soluble, rat, polyethylene glycol-conjugated TNF receptor type 1 (4 mg’kg body weight) before a single ip injection of LPS showed a significant reduction in circulating IL-6 levels but no effect on LPS-induced D2 mRNA in the majority of tanycytes with the exception of a subpopulation of alpha tanycytes in the wall of the third ventricle. LPS induced a rapid increase in Ikappa-Balpha mRNA in the pars tuberalis and a delayed response in alpha tanycytes but absent in all other tanycyte subsets. The LPS-induced increase in Ikappa-Balpha in the pars tuberalis was associated with increased TSHbeta gene expression in this tissue, but cAMP response element-binding protein (CREB) phosphorylation was observed only in a subset of alpha tanycytes. These data suggest that TNF and nuclear factor-kappaB signaling are not the primary, initiating mechanisms mediating the LPS-induced D2 response in tanycytes, but may contribute in part to sustaining the LPS-induced D2 response in a subset of alpha tanycytes. We hypothesize that in addition to TSH, other factors derived from the pars tuberalis may contribute to LPS-induced D2 activation in tanycyteses_ES
dc.description.monthAgoes_ES
dc.identifier1491es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1210/en.2010-0279es_ES
dc.identifier.eissn1945-7170es_ES
dc.identifier.issn0013-7227es_ES
dc.identifier.numero8es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion3827-3835es_ES
dc.identifier.placeEstados Unidoses_ES
dc.identifier.urihttps://doi.org/10.1210/en.2010-0279es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940536/es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6172
dc.identifier.volumen151es_ES
dc.language.isoenges_ES
dc.relation151 (8) 3827-3835 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoENDOCRINOLOGYes_ES
dc.relation.journalEndocrinologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koCyclic AMP Response Element-Binding Proteines_ES
dc.subject.kometabolismes_ES
dc.subject.koEnzyme Activationes_ES
dc.subject.kodrug effectses_ES
dc.subject.koGene Expression Regulation, Enzymologices_ES
dc.subject.kodrug effectses_ES
dc.subject.koHypothalamuses_ES
dc.subject.kodrug effectses_ES
dc.subject.koHypothalamuses_ES
dc.subject.koimmunologyes_ES
dc.subject.koHypothalamuses_ES
dc.subject.kometabolismes_ES
dc.subject.koI-kappa B Proteinses_ES
dc.subject.kogeneticses_ES
dc.subject.koI-kappa B Proteinses_ES
dc.subject.kometabolismes_ES
dc.subject.koImmune Systemes_ES
dc.subject.kodrug effects Immune Systemes_ES
dc.subject.kometabolismes_ES
dc.subject.koIodide Peroxidasees_ES
dc.subject.kogeneticses_ES
dc.subject.koIodide Peroxidasees_ES
dc.subject.kometabolismes_ES
dc.subject.koLipopolysaccharideses_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koLipopolysaccharideses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koNF-kappa Bes_ES
dc.subject.kometabolismes_ES
dc.subject.koNF-kappa Bes_ES
dc.subject.kophysiologyes_ES
dc.subject.koPhosphorylationes_ES
dc.subject.kodrug effectses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Sprague-Dawleyes_ES
dc.subject.koSignal Transductiones_ES
dc.subject.kodrug effectses_ES
dc.subject.koSignal Transductiones_ES
dc.subject.kophysiologyes_ES
dc.subject.koThyrotropines_ES
dc.subject.kogeneticses_ES
dc.subject.koThyrotropines_ES
dc.subject.kopharmacologyes_ES
dc.subject.koTumor Necrosis Factor-alphaes_ES
dc.subject.kometabolismes_ES
dc.subject.koTumor Necrosis Factor-alphaes_ES
dc.subject.kophysiologyes_ES
dc.subject.koCyclic AMP Response Element-Binding Proteines_ES
dc.subject.koI-kappa B Proteinses_ES
dc.subject.koLipopolysaccharideses_ES
dc.subject.koNF-kappa Bes_ES
dc.subject.koTumor Necrosis Factor-alphaes_ES
dc.subject.koThyrotropines_ES
dc.subject.koiodothyronine deiodinase type IIes_ES
dc.subject.koIodide Peroxidasees_ES
dc.titleContribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administrationes_ES
dc.typearticlees_ES

Files

Collections

Artículos de revista