Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias. Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", México, D.F.14370, México
dc.contributor.emailenoch@uaem.mx (Samuel Estrada-Soto)
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorPonce-Muñoz, Hildaes_ES
dc.creatorHidalgo-Figueroa, Sergioes_ES
dc.creatorNavarrete-Vázquez, Gabrieles_ES
dc.creatorEstrada-Soto, Samueles_ES
dc.date2015
dc.date.accessioned2025-09-10T18:31:53Z
dc.date.accessioned2026-03-27T15:32:35Z
dc.date.available2025-09-10T18:31:53Z
dc.date.issued2015
dc.date.published2015
dc.descriptionObjective: To determine the depressant-like effects and the possible mechanism of action of tilianin isolated from active methanol extract of Agastache mexicana (A. mexicana). Also, to establish the pharmacophoric requirements of tilianin, as a possible ligand of GABAA/BZD receptor, by the alignment of diazepam, CGS-9896 and diindole, using a previously described pharmacophoric model. Methods: Tilianin (30 to 300 mg/kg, ip. and 300 mg/kg, po.) and methanol crude extract (10 to 300 mg/kg, ip. and 300 mg/kg po.) from A. mexicana were evaluated for potential sedative and anxiolytic-like response drugs by using open-field, hole-board, cylinder of exploration, plus-maze and sodium pentobarbital-induced hypnosis mice methods. Results: Methanol extract and tilianin showed anxiolytic-like activity from a dosage of 30 mg/kg, ip. or 300 mg/kg, po. and were less potent than diazepam 0.1 mg/kg, a reference anxiolytic drug used. Moreover, depressant activity of both potentiates sodium pentobarbital (SP)-induced sleeping time. The anxiolytic-like effect of 30 mg/kg ip. observed for the extract and tilianin, by using the plus-maze model, was partially prevented in the presence of flumazenil (a GABAA/BZD antagonist, 5 mg/kg ip.) but not in the presence of WAY 100635 (a selective 5-HT1A receptor antagonist, 0.32 mg/kg, ip.). Pharmacophoric modeling alignments of three agonist of GABAA/BZD allow identify seven chemical features. Tilianin contains six of the seven features previously determined. Conclusions: Results indicate that tilianin is one of the bioactive metabolites in the anxiolytic-like activity of A. mexicana, reinforcing its central nervous system uses, where GABAA/BZD, but not 5-HT1A, receptors are partially involved.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/S1995-7645(14)60312-6
dc.identifier.eissn2352-4146
dc.identifier.issn1995-7645
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeIndia
dc.identifier.urihttps://doi.org/10.1016/S1995-7645(14)60312-6
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8408
dc.language.isoenges_ES
dc.publisherWolters Kluweres_ES
dc.relation8(3):185-190
dc.relation.jnabreviadoASIAN PAC J TROP MED
dc.relation.journalAsian Pacific Journal of Tropical Medicine
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAgastache mexicana
dc.subject.kwAnxiety
dc.subject.kwBenzodiazepine
dc.subject.kwCentral nervous system
dc.subject.kwSedative
dc.subject.kwTilianin
dc.titleDepressant effects of Agastache mexicana methanol extract and one of major metabolites tilianines_ES
dc.typeArtículoes_ES

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