Accumbal serotonin hypofunction and dopamine hyperfunction due to chronic stress and palatable food intake in rats

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dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México
dc.contributor.emailgortari@inprf.gob.mx (P. de Gortari)
dc.creatorGarcía-Luna, C.
dc.creatorEspitia-Bautista, E.
dc.creatorAlvarez-Salas, E.
dc.creatorSoberanes-Chávez, P.
dc.creatorGortari, P. de
dc.creator.identificadorhttps://orcid.org/0000-0002-9401-1856 (García-Luna, C.)
dc.creator.identificadorhttps://orcid.org/0000-0002-7625-3130 (Espitia-Bautista, E.)
dc.creator.identificadorhttps://orcid.org/0000-0002-0136-3319 (Alvarez-Salas, E.)
dc.creator.identificadorhttps://orcid.org/0000-0002-1924-4617 (Soberanes-Chávez, P.)
dc.creator.identificadorhttps://orcid.org/0000-0002-9402-2061 (Gortari, P. de)
dc.date2025
dc.date.accessioned2026-06-23T18:04:14Z
dc.date.issued2025
dc.date.published2025
dc.descriptionABSTRACTFeeding is regulated by energy homeostatic and pleasure-induced rewarding signals. Palatable food intake modifies serotonergic (5-HT) and dopaminergic (DA) pathways in nucleus accumbens, inducing neuronal maladaptations that favor hyperphagia for high-energy dense food and consequent obesity. Chronic stress is an environmental condition that increases the preference for palatable food by modulating brain DA and 5-HT metabolism. Objective: To evaluate the association between changes in accumbal 5-HT and DA metabolism and the effects of chronic stress, palatable food intake and their interaction with satiety/hunger condition. Methods: Wistar rats were housed in pairs (non-stressed) or individually (stressed), fed with chow or chocolate milk plus chow (Ch) for 2 weeks (4 groups); then 6 animals/group were 48 h fasted or maintained ad libitum; the rest were fasted and re-fed for 2 h either with chow or Ch. Results: Rats with prolonged high-energy density food intake and re-fed with chow showed reduced 5-HT metabolism, although there was no association with animals' feeding behavior. In contrast, after re-fed with palatable food, stressed chow-fed rats had increased 5-HT turnover, which decreased in Ch re-fed rats, supporting that palatable food might induce positive mood changes related to high extracellular 5-HT in limbic regions. Discussion: Rats with prolonged palatable food intake exhibited high accumbal DA turnover independently of stress exposure, supporting its relation with the development of high-energy dense food hyperphagia. As accumbal 5-HT and DA metabolism changed due to fasting or re-feeding, alterations could represent the interaction of energy homeostatic and hedonic feeding signaling in animals.
dc.formatPDF
dc.identifierJC28NC24
dc.identifier.doi10.1080/1028415X.2024.2417922
dc.identifier.eissn1476-8305
dc.identifier.issn1028-415X
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/133
dc.identifier.urihttps://doi.org/10.1080/1028415X.2024.2417922
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation28(7):773-787
dc.relation.jnabreviadoNUTR NEUROSCI
dc.relation.journalNutritional Neuroscience
dc.rightsAcceso Cerrado
dc.subject.kwStress
dc.subject.kwPalatable food
dc.subject.kwSerotonin
dc.subject.kwDopamine
dc.subject.kwNucleus accumbens
dc.subject.kwFeeding
dc.subject.kwHyperphagia
dc.subject.kwObesity
dc.titleAccumbal serotonin hypofunction and dopamine hyperfunction due to chronic stress and palatable food intake in rats
dc.typeArtículo

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